Nothing great in science has ever been done by men, whatever their powers, in whom the divine afflatus of the truth-seeker was wanting. Men of moderate capacity have done great things because it animated them
 Thomas Henry Huxley, The Advance of Science in the Last Half-Century (1887). copy citation

Context

“They have their weaknesses, their follies, their vanities, and their rivalries, like the rest of the world; but whatever by-ends may mar their dignity and impede their usefulness, this chief end redeems them. [B] Nothing great in science has ever been done by men, whatever their powers, in whom the divine afflatus of the truth-seeker was wanting. Men of moderate capacity have done great things because it animated them; and men of great natural gifts have failed, absolutely or relatively, because they lacked this one thing needful. True aim and method of research. To anyone who knows the business of investigation practically, Bacon's notion of establishing a company of investigators to work for 'fruits,' as if the pursuit of knowledge were a kind of mining operation and only required well-directed picks and shovels, seems very strange.” source