Samuel Johnson quote about reason from The History of Rasselas, Prince of Abissinia - Of the uncertainties of our present state, the most dreadful and alarming is the uncertain continuance of reason.
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Of the uncertainties of our present state, the most dreadful and alarming is the uncertain continuance of reason.
 Samuel Johnson, The History of Rasselas, Prince of Abissinia (1759). copy citation

Context

“«Ladies,» said Imlac, «to mock the heaviest of human afflictions is neither charitable nor wise. Few can attain this man's knowledge and few practise his virtues, but all may suffer his calamity. Of the uncertainties p. 164of our present state, the most dreadful and alarming is the uncertain continuance of reason.»
The Princess was recollected, and the favourite was abashed. Rasselas, more deeply affected, inquired of Imlac whether he thought such maladies of the mind frequent, and how they were contracted.
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