Manoel Sarno; Gielson A. Sacramento; Ricardo Khouri; Mateus S. do Rosário; Federico Costa; Gracinda Archanjo; Luciane A. Santos; Nivison Nery, Jr.; Nikos Vasilakis; Albert I. Ko; Antonio R. P. de Almeida

“ We report a case of a 20-year-old pregnant woman from Salvador, Brazil whose fetus had developed hydrops fetalis, a condition where there is abnormal accumulation of fluid in the fetus, as well as severe central nervous system defects such as microcephaly and hydranencephaly. After fetal demise, ZIKV RNA was detected in central nervous system tissues and amniotic fluid. The case report provides evidence that in addition to microcephaly, there may be a link between Zika virus infection and hydrops fetalis and fetal demise. ”

“ Given the recent spread of the virus, systematic investigation of spontaneous abortions and stillbirths may be warranted to evaluate the risk that ZIKV infection imparts on these outcomes.
Introduction
The current outbreak of microcephaly has raised speculations that Zika virus (ZIKV) causes a congenital syndrome. ZIKV, a mosquito-borne flavivirus, was detected in Brazil in early 2015 [1] , [2] and has rapidly spread throughout the Americas [3] . ”

“ An induced labor was performed when ultrasound examination in the 32nd gestational week showed fetal demise and delivered a female fetus with a weight of 930g and signs of microcephaly and arthrogryposis. ”