“ Cascara sagrada is one of the most useful of all laxatives, since not only does it empty the bowel of faecal matter, but it acts as a tonic to the intestine and tends to prevent future constipation. It is largely used in the treatment of chronic constipation. A single full dose of the liquid extract may be taken at bedtime, or divided doses, 10 to 15 minims, three times a day before meals. ”