Summary

Mishnah — Seder Nezikin, Tractate SanhedrinChapter 3…

A gambler, especially a dice-player, in which the game is entirely concerned with luck, expects to win something though the odds are against him. Thus they cannot serve as a witness. Another possible explanation is that one whose primary profession concerns luck is not of solid character to serve as a witness in even a monetary case.
Loan-sharks - because lending money at interest is considered a sin (until later Talmudic reforms) , these people are not allowed to serve as witnesses for the same reasons as dice-players.
Source: Wikisource

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