Plotinus

“ The separation takes place when nothing of the Soul remains bound up with it: the harmony within the body, by virtue of which the Soul was retained, is broken and it can no longer hold its guest.
But when a man contrives the dissolution of the body, it is he that has used violence and torn himself away, not the body that has let the Soul slip from it. ”

“ But if a man feel himself to be losing his reason?
That is not likely in the Proficient, but if it should occur, it must be classed with the inevitable, to be welcome at the bidding of the fact though not for its own sake. To call upon drugs to the release of the Soul seems a strange way of assisting its purposes. ”