Thomas Willis, A Plain and Easie Method for Preserving…
“ These are the chiefest Remedies which help to keep Infection out of the Body. There is yet another sort which serves to let it out, and carry it away, before it grows to a head, viz. Issues, which have been found by often experience to be good Preservatives in time of Plague: For as much as Nature having a constant vent for excrementitious matter thrown off the Blood, by the same way expels poysonous Atoms soon after they are receiv'd into the Body. ”
