Summary

Wiley Blount Rutledge Direct Sales Company v. United States…

The difference in the commodities has a further bearing upon the existence and the proof of intent. There may be circumstances in which the evidence of knowledge is clear, yet the further step of finding the required intent cannot be taken. Concededly, not every instance of sale of restricted goods, harmful as are opiates, in which the seller knows the buyer intends to use them unlawfully, will support a charge of conspiracy.
Source: Wikisource

Wiley Blount Rutledge Direct Sales Company v. United States…

So drug addicts furnish the normal outlet for morphine which gets outside the restricted channels of legitimate trade.
This difference is important for two purposes. One is for making certain that the seller knows the buyer's intended illegal use. The other is to show that by the sale he intends to further, promote and cooperate in it. This intent, when given effect by overt act, is the gist of conspiracy. While it is not identical with mere knowledge that another purposes unlawful action, it is not unrelated to such knowledge. Without the knowledge, the intent cannot exist.
Source: Wikisource

Wiley Blount Rutledge Direct Sales Company v. United States…

The step from knowledge to intent and agreement may be taken. There is more than suspicion, more than knowledge, acquiescence, carelessness, indifference, lack of concern. There is informed and interested cooperation, stimulation, instigation. And there is also a 'stake in the venture' which, even if it may not be essential, is not irrelevant to the question of conspiracy. [9] Petitioner's stake here was in making the profits which it knew could come only from its encouragement of Tate's illicit operations.
Source: Wikisource

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