John Locke quote about reason from An Essay Concerning Human Understanding - So that, in effect, religion, which should most distinguish us from beasts, and ought most peculiarly to elevate us, as rational creatures, above brutes, is that wherein men often appear most irrational, and more senseless than beasts themselves.
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So that, in effect, religion, which should most distinguish us from beasts, and ought most peculiarly to elevate us, as rational creatures, above brutes, is that wherein men often appear most irrational, and more senseless than beasts themselves.
 John Locke, An Essay Concerning Human Understanding (1689). copy citation

Context

“For men having been principled with an opinion, that they must not consult reason in the things of religion, however apparently contradictory to common sense and the very principles of all their knowledge, have let loose their fancies and natural superstition; and have been by them led into so strange opinions, and extravagant practices in religion, that a considerate man cannot but stand amazed, at their follies, and judge them so far from being acceptable to the great and wise God, that he cannot avoid thinking them ridiculous and offensive to a sober good man. So that, in effect, religion, which should most distinguish us from beasts, and ought most peculiarly to elevate us, as rational creatures, above brutes, is that wherein men often appear most irrational, and more senseless than beasts themselves. CREDO, QUIA IMPOSSIBILE EST: I believe, because it is impossible, might, in a good man, pass for a sally of zeal; but would prove a very ill rule for men to choose their opinions or religion by.
CHAPTER XIX.” source

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