Pengran Cao; Pingyao Xie; Xuebiao Wang; Jinmei Wang; Jinfeng Wei; Wen-yi Kang

“ The acute toxicity test of tilianin had not been done yet and there was no report about its toxicity. Therefore, both acacetin and tilianin may have a good pharmaceutical prospect. Being cheap, safe and effective, they are in line with the requirements of today’s market fort anti-thrombotic drugs. Of course, the mechanism underlying their anti-coagulation activity need to be further investigated. ”

“ Drug therapy has played an important role in the prevention and treatment this disease. Currently, on the medicinal market, there are only three main types of anti-thrombotic drugs, including anticoagulant drugs, anti-platelet drugs and thrombolytic drugs. However, these drugs generally have greater adverse reactions and their prices are quiet high. Therefore, developing a safe, effective and low-cost anti thrombotic drug is an urgent need for clinical drug therapy for this disease. ”

“ In view of its abundant wild resource and diverse biological activities, it is necessary to study on its chemical constituents and to elucidate its chemical constituents and biological activities.
Thrombotic disease is a serious threat to human life and health and its incidence is ranked the highest one among various diseases. The incidence of thrombotic has still been displaying an increasing tendency. In the recent years, the studies on thrombotic disease are becoming one of the key points and hot spots in modern medicine. ”

“ It has been shown that high-fat hyperlipidemia, obesity, hypertension, atherosclerosis, coronary heart disease, myocardial infarction, cerebral thrombosis and a series of cardiovascular and cerebrovascular diseases are associated with abnormal lipid metabolism. ”

“ Funding This work was funded by Henan Province University Science and Technology Innovation Team (16IRTSTHN019) , Industry & University Research Project in Henan Province (162107000038 and 152107000051) , Basic and Advance Project in Science and Technology Agency of Henan Province (142300410123 and 152300410064) , National cooperation project of Henan province (2015GH12) and Kaifeng City Science and Technology Innovation Talent (1509010) . ”

“ The above data were basically consistent with those reported in the reference [ [15] ] . Thus, compound 3 was identified as acacetin.
Compound 4: this compound was a white crystalline with mp at 240–245 °C. The molecular formula was determined to be C30H48O3. EI-MS m/z: 456 [M] +. ”