National Institute for Occupational Safety and Health

“ Transfer the liquid from the bubbler, quantitatively, to a graduated cylinder. Bring volume to 15 mL with distilled water.
CALIBRATION AND QUALITY CONTROL: 9. 10.
Prepare working standards (20 to 800 μg/10 mL) by adding appropriate aliquots of calibration stock solution to distilled water. Analyze working standards together with samples and blanks (steps 11 through 13) . Prepare a calibration graph of area vs. μg of maleic anhydride per 15 mL of sample. ”

“ Maleic anhydride is a powerful irritant. Avoid contact with skin, eyes, and respiratory tract [5] .
SAMPLING: 1. 2. 3. 4. 5.
6.
Calibrate each personal sampling pump with a representative sampler in line. Transfer 15 mL distilled water to a bubbler. Connect outlet arm of bubbler to a second empty bubbler and then to the sampling pump. Sample 40 to 500 L of air at an accurately known rate between 0.2 and 1.5 L/min. Seal bubbler for shipment in a suitable container in order to prevent damage during transit. ”

“ Backup Data Report for Maleic anhydride, prepared under NIOSH Contract 210-76-0123 (1977) . NIOSH Manual of Analytical Methods, 2nd. ed., V. 5, P&CAM 302, U.S. Department of Health, Education, and Welfare, Publ. (NIOSH) 78-175 (1978) . Geyer, R. and Saunders, G. A. Determination of Maleic Anhydride in Workplace Air by Reverse Phase HPLC, J. Chromatogr. , 368 (2) , 456-458 (1986) . Kallio, H. Determination of Trace Concentrations of Maleic Anhydride in Workplace Air, Khig. ”