Fan Chuo,
Translation:Manshu — Chapter 7
“ Traditionally the bark is harvested in March to May. The active ingredient, berberine, was supposedly used in China as a folk medicine by Shennong around 3000BCE according to The Classic of Herbal Medicine (神農本草經) , a lost book of herbal knowledge believed to be compiled from oral traditions around 200-250CE. There are two species: Phellodendron amurense is from north-eastern China and was probably the more common point of reference for Chinese like our author. That said, Phellodendron chinense grows in the Yunnan region and may have been known from Sichuan. ”
