Erasmus Darwin,
Zoonomia, or, the Laws of Organic Life…
(1796)
“ Why does the pain of the primary part of the association cease, when that of the secondary part commences? This is a question of intricacy, but perhaps not inexplicable. The pain of the primary part of these associated trains of motion was owing to too great stimulus, as of the stone at the neck of the bladder, and was consequently caused by too great action of the pained part. ”
