National Institute for Occupational Safety and Health

“ Urinary butoxyacetic acid (BAA) is a biomarker of exposure to 2-butoxyethanol and 2-butoxyethyl acetate. Both 2-butoxyethanol and 2-butoxyethyl acetate are metabolized to butoxyacetic acid (BAA) and N-butoxyacetylglutamine, which are excreted in urine [1] . Since BAA produces the adverse hematogic effects attributed to exposures to 2-butoxyethanol and 2-butoxyethyl acetate, urinary BAA serves also as a biomarker to these particular exposure-related adverse health effects [2] . ”

“ BAA levels up to 282 :m ol/m ol creatinine (3 30 m g/g creatinine) have been m easured in occupation ally exposed persons [7] . Levels as high as 0.5 :m ol/m ol creatinine (0.6 m g/g creatinine) have been fou nd in urine of p eople not occupationally exposed to 2-butoxyethanol or 2-butoxyethyl acetate [6] . 2-Butoxyethanol is comm only found in household products, such as paints and cleaners. ”

“ Determination of butoxyacetic acid and n-butoxyacetylglutamine in urine of lacquerers exposed to 2-butoxyethanol, Int Arch Occup Environ He alth, 65, S151-S153. NIOSH [1990] . Criteria for a Recom mended Standard. Occupational exposure to ethylene glycol m onobutyl ether and ethylene glycol monobutyl ether acetate, DHHS (NIOSH) Publication No. ”