National Institute for Occupational Safety and Health

“ Sampler: glass tube, 7 cm long, 6-mm OD, 4mm ID, flame-sealed ends, containing two sections of 20/40 mesh petroleum-based charcoal (100 mg front/50 mg back) separated by a 2-mm urethane foam plug. A silylated glass wool plug precedes the front section and a 3-mm urethane foam plug follows the back section. Pressure drop across the tube at 1 L/min must be less than 3.4 kPa. Tubes are commercially available. 2. Personal sampling pump, 0.01 to 1 L/min, with flexible connecting tubing. 3. ”

“ Work with it only in a hood. Isophorone is a lachymator [3] ; work with it should be done in a hood and caution should be taken while it is being used.
SAMPLING: 1. 2. 3. 4.
Calibrate each personal sampling pump with a representative sampler in line. Break the ends of the sampler immediately before sampling. Attach sampler to personal sampling pump with flexible tubing. Sample at an accurately known flow rate between 0.01 and 1.0 L/min for a total sample size of 2 to 25 L. Cap the samplers with plastic (not rubber) caps and pack securely for shipment.
SAMPLE PREPARATION: 5. 6. 7. ”

“ High humidity will greatly decrease breakthrough volume.
INTERFERENCES: None identified. Alternate columns may be used, e.g., 10% SP-1000 or DB-2 fused silica capillary column.
OTHER METHODS: This is Method S367 with a different column recommended [2] .
NIOSH Manual of Analytical Methods (NMAM) , Fourth Edition, 8/15/94 ISOPHORONE: METHOD 2508, Issue 2, dated 15 August 1994 - Page 2 of 3 REAGENTS: 1. 2. 3. 4. 5. ”