Summary

Portrait of Alexis Thomson Alexis Thomson Manual of Surgery, Sixth Edition… (1921)

Sapraemia#, or septic intoxication, is the name applied to a form of poisoning resulting from the absorption into the blood of the toxic products of pyogenic bacteria. These products, which are of the nature of alkaloids, act immediately on their entrance into the circulation, and produce effects in direct proportion to the amount absorbed. As the toxins are gradually eliminated from the body the symptoms abate, and if no more are introduced they disappear.
Source: Wikisource

Portrait of Alexis Thomson Alexis Thomson Manual of Surgery, Sixth Edition… (1921)

Infection always takes place through a breach of the surface, although this may be superficial and insignificant, such as a pin-prick, a scratch, or a crack under a nail, and the wound may have been healed for some time before the inflammation becomes manifest. The cellulitis, also, may develop at some distance from the seat of inoculation, the organisms having travelled by the lymphatics.
Source: Wikisource

Portrait of Alexis Thomson Alexis Thomson Manual of Surgery, Sixth Edition… (1921)

The primary infection is usually in a wound--for example, a compound fracture--but cases occur in which the point of entrance of the bacteria is not discoverable. The dissemination of the organisms takes place through the medium of infected emboli which form in a thrombosed vein in the vicinity of the original lesion, and, breaking loose, are carried thence in the blood-stream. These emboli lodge in the minute vessels of the lungs, spleen, liver, kidneys, pleura, brain, synovial membranes, or cellular tissue, and the bacteria they contain give rise to secondary foci of suppuration.
Source: Wikisource

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