National Institute for Occupational Safety and Health

Name: NIOSH Manual of Analytical Methods — Aldehydes, Screening (2539)
Author: National Institute for Occupational Safety and Health

NIOSH Manual of Analytical Methods… (1994)

Summary

“NIOSH Manual of Analytical Methods — Aldehydes, Screening (2539)”, published in 1994, is a work by National Institute for Occupational Safety and Health. It explores elements such as aldehyde, oxazolidines and toluene.

Quotes from NIOSH Manual of Analytical Methods… (National Institute for Occupational Safety and Health)

National Institute for Occupational Safety and Health, NIOSH Manual of Analytical Methods… (1994)

“ The molecular ion for a particular aldehyde is equal to the molecular weight of the original aldehyde plus 97. Fragmentation patterns are also important for the identification of the oxazolidines. NOTE 2: The absence of some C 3-C 5 aldehydes, such as propionaldehyde, isobutyraldehyde and crotonaldehyde, does not necessarily mean that these compounds are not present in the air sampled. These compounds are not efficiently trapped by the sorbent, and will readily breakthrough the sampler sorbent beds. ”

[↩︎]

Source: Wikisource

National Institute for Occupational Safety and Health, NIOSH Manual of Analytical Methods… (1994)

“ For the other aldehydes, add measured aliquots (ca. 12 :L) of each to toluene in 10-mL volumetric flasks and dilute to the mark. From the density of each aldehyde, determine the amount of each aldehyde present in each solution (ca. 1 :g/:L) . b. Inject 10 :L of the standard aldehyde solutions separately onto blank tubes from the same lot as the field samples. c. Analyze (steps 4 through 7 and 10 through 12) along with blanks for qualitative identification of derivative peaks by retention times. ”

[↩︎]

Source: Wikisource

National Institute for Occupational Safety and Health, NIOSH Manual of Analytical Methods… (1994)

“ METHOD 2539, Issue 2, dated 15 August 1994 - Page 4 of 10 chrom atogram ) . a. Analyze samples with GC retention times matching any oxazolidine by GC/MS using the same GC columns and conditions if possible. Alternate columns such as a DB-WAX (formaldehyde, acetaldehyde, propanal) or DB-1 (remaining aldehydes) may also be used for GC/MS confirmation depending on which aldehyde is suspected. b. Determine the presence of oxazolidines by monitoring for specific ions known to be present in the derivative spectra. ”

[↩︎]

Source: Wikisource

National Institute for Occupational Safety and Health, NIOSH Manual of Analytical Methods… (1994)

“ To determine the amount of background for each batch, extract several 120-mg portions of the coated sorbent with toluene and analyze (steps 6 through 12) . No blank peak is expected for any aldehydes other than formaldehyde and possibly acetaldehyde. SYNTHESIS OF ALDEHYDE OXAZOLIDINES: Plac e a so lution of pu rified 2-hyd roxym ethylp iperid ine (0 .57 g , 5 m mo l) in 10 mL of tolu ene in a 50-mL round-bottomed flask. Use several 20 mL portions of toluene to rinse residual 1- (hydrox ymethyl) p iperidine fro m the containe r used fo r weighing . ”

[↩︎]

Source: Wikisource

National Institute for Occupational Safety and Health, NIOSH Manual of Analytical Methods… (1994)

“ Certain aldehydes are also suspect carcinogens. Work with these compounds only in a well-ventilated hood. SAMPLING: 1. 2. 3.
Calibrate each personal sampling pump with a representative sampler in line. Break ends of the sampler immediately before sampling. Attach sampler to personal sampling pump with flexible tubing. For general screening, sample at 0.01 to 0.05 L/min for a maximum sample volume of 5 L. NOTE: Aldehydes react with the 2- (hydroxymethyl) piperidine to form an oxazolidine derivative in the sorb ent b ed d urin g sa mp ling. ”

[↩︎]

Source: Wikisource

National Institute for Occupational Safety and Health, NIOSH Manual of Analytical Methods… (1994)

“ Standardize by placing 5.0 mL of freshly prepared 1.13 M sodium sulfite solution in a 5 0-m L beak er and s tir magn etically. Adjust p H to betw een 8.5 a nd 10 w ith base o r acid. Record the pH. Add 10.0 mL stock formaldehyde solution. The pH should be greater than 11. ”

[↩︎]

Source: Wikisource

National Institute for Occupational Safety and Health, NIOSH Manual of Analytical Methods… (1994)

“ C7 H1 3 NO C8 H1 5 NO C9 H1 7 NO C9 H1 5 NO C1 0 H1 9 NO C1 0 H1 9 NO C1 0 H1 7 NO C1 1 H2 1 NO C1 1 H2 1 NO C1 2 H2 3 NO C1 3 H2 5 NO C1 1 H1 5 NO2
HMP DERIVATIVE Base Peak m/z 97 126 126 126 126 126 126 126 126 126 126 192
Other Characteristic Ions m/z 126, 127* 140, 141* 154, 155* 152, 153* 168, 169* 168, 169* 166, 167* 182, 183* 182, 183* 196, 197* 210, 211* 95, 163, 193*
indicates molecular ion. APPENDIX A: SORBENT PREPARATION (optional if commercially prepared tubes are used ) : Extrac t Amb erlite XAD S-2 for 4 h in Soxh let with 50/50 (v/v) aceto ne/m ethylene ch loride. ”

National Institute for Occupational Safety and Health

Summary

Quotes from NIOSH Manual of Analytical Methods… (National Institute for Occupational Safety and Health)

Common terms

Similar works

Get perspective with Kwize: daily news enlightened by great literature