National Institute for Occupational Safety and Health

“ Dimethyl sulfate is a suspect carcinogen, and both the liquid and vapor are extremely severe irritants to skin, eyes, and mucous membranes. It is an insidious hazard -- warning properties are poor and symptoms are delayed up to 10 h or more [3,4] . All transfers involving dimethyl sulfate should be performed in a fume hood. Personal protective equipment should be used to prevent any bodily exposure even to the vapor. ”

“ Set gas chromatograph according to manufacturer's recommendations and to conditions given on page 2524-1. Set electrolytic conductivity detector for operation in sulfur mode according to manufacturer's recommendations. ”

“ Allow to stand 30 min with occasional agitation.
CALIBRATION AND QUALITY CONTROL: 8.
9.
10.
Calibrate daily with at least five working standards over the range 0.25 to 120 μg dimethyl sulfate per sample (2.5 to 1200 μg/10 mL) . a. Add known amounts of calibration stock solution to 10-mL volumetric flasks and dilute to the mark with diethyl ether. b. Analyze together with samples and blanks (steps 11 and 12) . c. Prepare calibration graph (peak area vs. μg dimethyl sulfate) . ”