National Institute for Occupational Safety and Health

Name: NIOSH Manual of Analytical Methods — 1,3-Butadiene (1024)
Author: National Institute for Occupational Safety and Health

NIOSH Manual of Analytical Methods… (1994)

Summary

“NIOSH Manual of Analytical Methods — 1,3-Butadiene (1024)”, published in 1994, is a work by National Institute for Occupational Safety and Health. It explores elements such as butadiene, sample and recovery.

Quotes from NIOSH Manual of Analytical Methods… (National Institute for Occupational Safety and Health)

National Institute for Occupational Safety and Health, NIOSH Manual of Analytical Methods… (1994)

“ Convert gas volumes to masses, correcting for compressibility and water vapor (see APPENDIX B) , and prepare DE calibration graph of peak area or height vs. μg/mL 1,3-butadiene. d. Read the concentrations, μg/mL, in media standards and blanks from DE calibration graph and multiply by the desorption volume to calculate the masses recovered. e. Prepare a graph of DE vs. μg taken. DE = (mass found – blank mass) / (mass taken) . 12.
Analyze three quality control blind spikes to insure that calibration graph (step 10) is in control. ”

[↩︎]

Source: Wikisource

National Institute for Occupational Safety and Health, NIOSH Manual of Analytical Methods… (1994)

“ When exposed to 0.7 and 2.5 mL of pure 1,3-butadiene gas followed by 80% RH air, breakthrough occurred after 35 L and 28.5 L, respectively. The corresponding respective timeweighted average concentrations were 20 and 88 ppm. For the analysis of media standards at levels of 1.1, 4.4, 18, 125, and 480 μg per sample, the pooled was 0.025, and the desorption efficiencies were 67%, 68%, 75%, 102%, and 97%, respectively. Adding water to media standards just after spiking or during desorption had no significant effect on desorption efficiencies. ”

[↩︎]

Source: Wikisource

National Institute for Occupational Safety and Health, NIOSH Manual of Analytical Methods… (1994)

“ Subsequently, simulated samples were exposed to known amounts of approximately 10% 1,3-butadiene in helium, followed by 25 L of air at 80% RH. The 1,3-butadiene concentration was independently determined by packed column gas chromatography with thermal conductivity detection. Media standards were prepared via calibrated sampling valves. The recovery from six simulated samples at 463 μg per sample was 101.6% versus media standards and 91.3% versus standard solutions ”

[↩︎]

Source: Wikisource

National Institute for Occupational Safety and Health, NIOSH Manual of Analytical Methods… (1994)

“ The working range is 0.02 to 100 ppm (0.04 to 220 mg/m3) for a 25-L air sample. At the higher levels, desorbed samples may require dilution. Below 0.9 mg/m3 (0.4 ppm) , the desorption efficiency falls below 75% and allowance should be made for decreased accuracy.
INTERFERENCES:
Pentane, methyl acetylene, or vinylidene chloride may chromatographically interfere at high levels. High humidity (>80% RH) or other hydrocarbons present at permissible levels may significantly decrease the sampler’s capacity for 1,3-butadiene. ”

[↩︎]

Source: Wikisource

National Institute for Occupational Safety and Health, NIOSH Manual of Analytical Methods… (1994)

“ This establishes a reverse flow of 10 mL/min through the pre-column. Program the oven to hold the initial temperature (50 °C) for 2 min, then rise to 120 °C at 20 °C/min, and hold for 8 min. Adjust the time from injection to backflush by injecting standards and progressively decreasing the time from 2 min until the methylene chloride peak is removed without attenuating the butadiene peak. It may be necessary to clear higher hydrocarbons from the analytical column by programming the oven to 200 °C at 30 °C/min and holding 4 min. ”

[↩︎]

Source: Wikisource

National Institute for Occupational Safety and Health, NIOSH Manual of Analytical Methods… (1994)

“ Program the solenoid valves to be activated after each run to prepare for the next injection. Using the backflushable pre-column, there remains a slight problem with retention drift. While in inject mode, the pre-column strips residual water from the carrier gas. This activates the aluminum oxide surface of the analytical column and causes retention to increase. ”

[↩︎]

Source: Wikisource

National Institute for Occupational Safety and Health, NIOSH Manual of Analytical Methods… (1994)

“ Vials, 5-mL, 2-mL, 1-mL, and other convenient sizes, with PTFE-lined septum caps. Pipettes, TD, 4-, 2-, and 1-mL. Syringes, gas-tight, 250-, 100-, 25-, and 10-μL. Beaker, 150-mL. Gas drying tube with serum cap to fit stem and 2-cm piece of plastic tubing to fit over serum cap. SPECIAL PRECAUTIONS: 1,3-Butadiene is a potential carcinogen, teratogen, and reproductive hazard [2] . Methylene chloride is toxic, very volatile, and a suspect carcinogen [3] . Work should be performed in a well-ventilated fume hood. ”

National Institute for Occupational Safety and Health

Summary

Quotes from NIOSH Manual of Analytical Methods… (National Institute for Occupational Safety and Health)

Common terms

Similar works

Get perspective with Kwize: daily news enlightened by great literature