National Institute for Occupational Safety and Health

“ State surface contamination limits are provided as an aid to those seeking additional information and does not constitute endorsement by NIOSH. The National Alliance for Model State Drug Laws (NAMSDL) website: http://www.namsdl.org/ home.htm periodically summarizes state feasibility-based decontamination limits and proposed state legislative requirements and guidelines. ”

“ For further information and data on the effects of surface composition and porosity as well as the use of different solvents on the efficacy of wipe sampling, please see reports by Martyny [6, 7] . 1.
Follow specific requirements of surface area to be wiped (usually 100 cm2) and action threshold (or maximum allowable residual level) set by the agency having legal jurisdiction or specified by the client. Uptake rates depend upon the wipe sampling method used so the specific wipe technique used must be specified and any deviations from the required wipe sampling requirements noted. 2. ”

“ Calibrate daily with at least six media spiked calibration standards and a blank. a. Prepare the target analyte spiking solutions. (See SOLUTIONS, 9111-2) b. Prepare calibration standards and media blanks in clean shipping containers (e.g. 50-mL polypropylene centrifuge tubes.) c. Spike a known volume of target analyte spiking solution into each calibration standard by spiking directly onto the media. Use the spiking volumes suggested in Table 3 to cover the desired range. ”

“ Desorption from media: a. Remove cap from shipping container. Sample media should fit loosely in the container. If not, rearrange media carefully with rinsed forceps or transfer to a larger container. If the sample media are transferred to a larger container, do not discard the original container. Samples may consist of more than one wipe. If this is the case, internal standard and desorption solution volumes may be adjusted accordingly. b. Spike exactly 50 μL of internal standard spiking solution onto each wipe sample. c. Add 30 mL desorption solution (0.1 M sulfuric acid) . ”

“ Clandestine drug labs may produce unknown and seriously toxic by-products.
Method rev. 1.1.1
NIOSH Manual of Analytical Methods (NMAM) , Fifth Edition METHAMPHETAMINE on Wipes by LC/MS : METHOD 9111, Issue 1, dated 17 October 2011 - Page 3 of 12
SAMPLING: See APPENDIX for special instructions on sampling. 1.
Using a new pair of gloves, remove a gauze wipe from its protective package. Moisten the wipe with approximately 3 to 4 mL of methanol (or isopropanol) . NOTE 1: Apply no more solvent than that needed to moisten approximately the central 80% of the area of the gauze wipe. ”

“ In general, if the area wiped was greater than or less than 100 cm2, do not convert value to μg/100 cm2. To avoid confusion, report separately both μg/sample (C) and the total area wiped in cm2 per sample (A) for both discrete and composite samples. EVALUATION OF METHOD: This method was evaluated for methamphetamine over a range of approximately 0.4 μg/sample to 17.8 μg/sample on cotton gauze. These concentration levels represent approximately 3 through 100 times the limit of quantitation (LOQ) level. Results are reported in the Backup Data Report for 9111s [1] . ”