William Bateson

“ But we cannot admit the plausibility of an argument which demands on the one hand that the extreme precision with which species A adheres in the minutest details of its colour and pattern to a certain type shall be ascribed to the protective fitness of those details, and on the other hand that the abundant variability of species B shall be ascribed to the same determination. If it is absolutely necessary for A to conform to one type how comes it that B may range through some twenty distinct forms, any two of which differ more from each other than the regular species of many other genera? ”

“ I know nothing which to a man well trained in scientific knowledge and method brings so vivid a realisation of our ignorance of the nature of life as the mystery of cell-division. What is a living thing? The best answer in few words that I know is one which my old teacher, Michael Foster, used to give in his lectures introductory to biology. "A living thing is a vortex of chemical and molecular change." ”

“ I trust that some one with the right intellectual equipment will endeavor to follow this guide; and I am sanguine enough to think that a comprehensive study of the geometrical phenomena of differentiation will suggest to a penetrative mind that critical experiment which may one day reveal the meaning of spontaneous division, the mystery through which lies the road, perhaps the most hopeful, to a knowledge of the nature of life. ”

“ In the enthusiasm with which evolutionary ideas were received the specificity of living things was almost forgotten. The exactitude with which the members of a species so often conform in the diagnostic, specific features passed out of account; and the scientific world by dwelling with a constant emphasis on the fact of variability, persuaded itself readily that species had after all been a mere figment of the human mind. ”

“ It is I fear a problem rather for the physicist than for the biologist. The sentiment may not be a popular one to utter before an assembly of biologists, but looking at the truth impersonally I suspect that when at length minds of first rate analytical power are attracted to biological problems, some advance will be made of the kind which we are awaiting.
The study of the phenomena of bodily symmetry offers perhaps the most hopeful point of attack. The essential fact in reproduction is cell-division, and the essential basis of hereditary resemblance is the symmetry of cell-division. ”

“ Genetics thus cease to be merely a method of investigating theories of evolution or of the origin of species but provide a novel and hitherto untried instrument by which the nature of the living organism may be explored. Just as in the study of non-living matter science began by regarding the external properties of weight, opacity, colour, hardness, mode of occurrence, etc., noting only such evidences of chemical attributes and powers as chance spontaneously revealed ”

“ If we could conceive of an organism like one of those to which disease may be due becoming actually incorporated with the system of its host, so as to form a constituent of its germ-cells and to take part in the symmetry of their divisions, we should have something analogous to the case of a species which acquires a new factor and emits a dominant variety. ”

“ Consider the group of species composing the agrestis section of the genus Veronica, namely Tournefortii, agrestis, and polita.
These three grow side by side in my garden, as they do in suitable situations over a vast area of the temperate regions. I have for years noticed them with some care and become familiar with their distinctions and resemblances. Never is there any real doubt as to the identity of any plant. The species show some variability, but I have never seen one which assumed any of the distinguishing features of the others. ”

“ Are we not then on safer ground in regarding the fixity of our species as a property inherent in its own nature and constitution? Just as in ages of domestication no rose has ever given off a blue variety so has the pheasant never broken out into the polymorphism of the Ruff.
As soon as it is realised how largely the phenomena of variation and stability must be an index of the internal constitution of organisms, and not mere consequences of their relations to the outer world, such phenomena acquire a new and more profound significance. ”

“ If they were proved to enter from without, like pathogenic organisms, we should have to account for the extraordinary fact that they are distributed with fair constancy to half the gametes of the heterozygote.
In proportion as the nature of dominants grows more clear so does it become increasingly difficult to make any plausible suggestion as to their possible derivation. On the other hand the origin of a recessive variety by the loss of a factor is a process so readily imagined that our wonder is rather that the phenomenon is not observed far more often. ”

“ We still know little enough of the mode of occurrence of variation, but we do begin to know something, and if we ask ourselves whether our knowledge, such as it is, conforms at all readily with our former expectations, we cannot with any confidence assert that it does. Among the plants and animals genetically investigated are many illustrations of very striking and distinct varieties. Many of these might readily enough be accepted as species by even the most exacting systematists, and not a few have been so treated in classification ”

“ Now since variation consists as much in meristic change as in alteration in substance or material, there is one great range of problems of causation from which we are as yet entirely cut off. We know nothing of the causation of division, and we have scarcely an observation, experiment or surmise touching the causes by which the meristic processes may be altered.
Of the way in which variations in the substantive composition of organisms are caused we have almost as little real evidence, but we are beginning to know in what such variations must consist. ”

“ On attempting a more general discussion of the bearing of the phenomena on the theory of Evolution, I found myself continually hindered by the consciousness that such treatment is premature, and by doubt whether it were not better that the debate should for the present stand indefinitely adjourned. That species have come into existence by an evolutionary process no one seriously doubts; but few who are familiar with the facts that genetic research has revealed are now inclined to speculate as to the manner by which the process has been accomplished. ”

“ How, they may ask, can any force competent to produce chemical and geometrical differentiation in the body be distinguished from the "Entelechy" of Driesch? Let me admit that in this reflexion there is one element of truth. If those who proclaim a vitalistic faith intend thereby to affirm that in the processes by which growth and division are effected in the body, a part is played by an orderly force which we cannot now translate into terms of any known mechanics, what observant man is not a vitalist? ”

“ The two species therefore, apart from any differences that we can suppose to be related to their respective habits, are characterised by small fixed distinctions in colour-markings, by a striking difference in secondary sexual characters, and by a difference in variability. In all these respects we can form no surmise as to any economic reason why the one species should be differentiated in the one way and the other in the other way, and I believe it is mere self-deception which suggests the hope that with fuller knowledge reasons of this nature would be discovered. ”

“ Making every deduction for the fact that the wonders of adaptation have been grossly exaggerated, and that marvels of fitness and correspondence between means and ends have grown out of mere anthropomorphic speculations, there is much more left to be accounted for than can at all comfortably be accepted as the product of happy accidents. So oppressive are these difficulties that we can scarcely blame those who imagine that the study of heredity is primarily directed to the problem of the transmission of acquired characters, a preconception still almost universal among the laity. ”

“ If we glance at the history of the scientific conception of Species we find many signs that it was not till comparatively recent times that the definiteness of species became a strict canon of the scientific faith and that attempts were made to give precise limits to that conception. When the diversity of living things began to be accurately studied in the sixteenth and seventeenth [Pg 4] centuries names were applied in the loosest fashion, and in giving a name to an animal or a plant the naturalists of those times had no ulterior intention. ”

“ Phenomena of Division I have said that in the division of a cell we seem to see the problem in its simplest form, but it is important to observe that the problem of division may be presented by the bodies of animals and plants in forms which are independent of the divisions between cells. The existence of pattern implies a repetition of parts, and repetition of parts when developed in a material originally homogeneous can only be created by division. ”

“ In frankly recognizing that the fixity of characters in general need not connote usefulness to their possessors we deliver ourselves of a distracting pre-occupation and prepare our minds for an investigation of the properties of living organisms in the same spirit as that in which the chemist and the physicist examine the properties of unorganized materials. The creature persists not merely by virtue of its characteristics but in spite of them, and the fact of its persistence proves no more than that on the whole the balance of its properties leaves something in its favour. ”

“ The outstanding fact that emerges prominently from the study of the local forms is that when two definite types, nearly allied, and capable of interbreeding with production of fertile offspring, meet together in the region where their distributions overlap, though intergrades are habitually found, there is no normally or uniformly intermediate population occupying the area of intergradation. Such phenomena as these must, I think, be admitted to have great weight in any attempt to construct a theory of evolution. ”

“ I cannot understand the attitude of those who, contemplating such facts as this examination elicits, can complacently declare that specific difference is a mere question of degree. With the spread of evolutionary ideas to speak much of the fixity of species has become unfashionable, and yet how striking and inscrutable are the manifestations of that fixity! ”

“ If we are going to explain what happens in our harmonious-equipotential systems by the aid of causality based upon the constellation of single chemical factors and events, there must be some such thing as a machine. Now the assumption of the existence of a machine proves to be absolutely absurd in the light of the experimental facts. Therefore there can be neither any sort of a machine nor any sort of causality based upon constellation underlying the differentiation of harmonious-equipotential systems. ”

“ When we see these various Veronicas each rigidly reproducing its parental type, all comfortably surviving in competition with each other, are we not forced to the conclusion that tolerance has as much to do with the diversity of species as the stringency of Selection? Certainly these species owe their continued existence to the fact that they are each good enough to live, but how shall we refer the distinctions between them directly or indirectly to the determination of Natural Selection? ”

“ To make clear the application of the terms chemical and mechanical to the problem of Genetics the nature of that problem must be more fully described. In its most concrete form this problem is expressed in the question, how does a cell divide? If the organism is unicellular, and the single cell is the whole body, then the process of heredity is accomplished in the single operation of cell-division. Similarly in animals and plants whose bodies are made up of many cells, the whole process of heredity is accomplished in the cell-divisions by which the germ-cells are formed. ”

“ Something has come from the work of systematists, something from cultural experiments, something from the direct study of variation as it appears in nature, but progress is especially due to experimental investigation of heredity. From all these lines of inquiry we get the same answer; that what the naturalists of fifty years ago regarded as variation is not one phenomenon but many, and that what they would have adduced as evidence against the definiteness of species may not in fact be capable of this construction at all. ”

“ It is most difficult to form a clear judgment of the value of the evidence as a whole. To doubt the validity of testimony put forward by reputable authors is to incur a charge of obstinacy or caprice; nevertheless in matters of this kind, where the alleged phenomena are, if genuine, of such exceptional significance, belief should only be extended to evidence after every possible source of doubt has been excluded. We believe such things when we must, but not before. At the very least we are entitled to require that confirmatory evidence should be forthcoming from independent witnesses. ”

“ We know, of course, that the phenomenon of specific diversity is complicated by local differentiation: that, in general, forms which cannot disperse themselves freely exhibit a multitude of local races, and that of these some are obviously adaptative, and that a few even owe their peculiarity to direct environmental effects. ”

“ To supply themselves with food, to find it, to seize and digest it, to protect themselves from predatory enemies whether by offence or defence, to counter-balance the changes of temperature, or pressure, to provide for mechanical strains, to obtain immunity from poison and from invading organisms, to bring the sexual elements into contact, to ensure the distribution of the type; all these and many more are accomplished by organisms in a thousand most diverse and alternative methods. ”

“ If we no longer see how varieties give rise to species, we may feel confident that a minute study of genetic physiology of varieties and species is the necessary beginning of any critical perception of their inter-relations. It is little more than a century since no valid distinction between a mechanical mixture and a chemical combination could be perceived, and in regard to the forms of life we may well be in a somewhat similar confusion.
As yet the genetic behaviour of animals and plants has only been sampled. ”

“ Before any indisputable progress can be made with the problem of evolution it is necessary that we should acquire some real knowledge of the genesis of that class of phenomena which formed the subject of the last chapter. So long as the process of division remains entirely mysterious we can form no conception [Pg 86] even of the haziest sort as to the nature of living organisms, or of the proximate causes which determine their forms, still less can we attempt any answer to those remoter questions of origin and destiny which form the subject of the philosopher's contemplation. ”

“ Not only is this specificity thus universally present among the different forms of life, but it manifests itself in respect of the most diverse characteristics which living things display. Species may thus be distinguished by peculiarities of form, of number, of geometrical arrangement, of chemical constitution and properties, of sexual differentiation, of development, and of many other properties. In any one or in several of these features together, species may be found distinguished from other species. ”

“ It is possible that in Man twinning is due to a peculiarity of the mother, not of the father. It may and not rarely does descend from mother to daughter, but whether it can be passed on through a male generation to a daughter again, there is not sufficient evidence to show. The facts as far as they go are consistent with the inference which may be drawn from Loeb's experiment, that the twinning of a fertilized ovum may be determined not by the germ-cells which united to form it, but by the environment in which it begins to develop. ”

“ Such methods obviously were to be found in a critical and exhaustive study of the facts of variation and heredity, upon which all conceptions of evolution are based. To construct a true synthetic theory of Evolution it was necessary that variation and heredity instead of being merely postulated as axioms should be minutely examined as phenomena. Such a study Darwin himself had indeed tentatively begun, but work of a more thorough and comprehensive quality was required. ”

“ All that we can say at the present time is that the incidence both of hybrid sterility, and of incompatibility also, is most capricious; and provided that two forms have such features in common that a cross between them seems not altogether out of the question, no one can predict without experiment whether such a cross is feasible, and if feasible whether the product will be fertile, or sterile more or less completely. ”

“ Abnormalities abound in the experience of everyone who examines pans of seedlings of almost any species of plant, and in maize they are well known to be exceptionally common. Some of those which we meet with when we attempt to ripen maize in this country are very similar to those which Blaringhem describes, consisting in irregularities in the distribution of the sexes, in the shapes of the panicles, etc. Many of these are doubtless imperfections of development, due to the dullness of our climate, but others are presumably genetic and would recur in the offspring however treated. ”

“ For apart from any question of the justice of these wider inferences, if we examine the phenomenon of specificity as it appears in those examples which are nearest to hand, surely we find signs in plenty that specific distinction is no mere consequence of Natural Selection. The strength of this proposition has lain mainly in the appeal to ignorance. Steadily with the growth of knowledge has its cogency diminished, and such a belief could only have been formulated at a time when the facts of variation were unknown. ”