Poison gland

“ Another species of poison, allied to the preceding in its effects and equally obscure in its nature, includes certain fluids of the human body after natural death, which are probably modified, if not even formed altogether, by morbid processes during life. Such poisons are the most frequent source of the dreadful cellular inflammation, often witnessed as the consequence of pricks received during dissection by the anatomist. ”

“ As the cause sometimes becomes a matter of legal investigation, it is very important that the practitioner should be able to determine the real origin. If caused by poison, the disease is very suddenly developed, the patient complaining of a very intense burning sensation in the throat and the lining membrane of the mouth, which will generally show the action of the poison. A diarrhea is also more apt to accompany the disease. If inorganic or vegetable poisons are known or suspected irritants, the appropriate antidotes should be promptly administered. ”

“ For example, in the case of the pure corrosives or irritants, the injury caused will depend for its danger on the importance of the organ to the general economy of the body: Inflammation caused by a local poison in the stomach will be more quickly fatal than that excited in the intestines only; and such a poison may act violently on the external parts without materially impairing the general health. ”

“ Thus, for example, the following cases will show, that there may be found in the dead body diseased appearances, arising from pleurisy, hydrothorax, or peripneumony, sufficient to cause death, or to account for death in ordinary circumstances; and that nevertheless the disease may have been completely latent, and death have arisen from poison. In Rust’s Magazin is related the case of a German apothecary, who poisoned himself with prussic acid, and in whose body the lower lobe of the left lung was found consolidated and partly cartilaginous. ”

“ Almost every virulent poison known to man is found in allopathic prescriptions. It is now positively proved by the Diagnosis from the Eye that these poisons have a tendency to accumulate in the system, to concentrate in certain parts and organs for which they have a special affinity and then to cause continual irritation and actual destruction of tissues. By far the greater part of all chronic diseases are created or complicated on the one hand by the suppression of acute diseases by means of drug poisons, and on the other hand through the destructive effects of the drugs themselves. ”

“ It was at one time thought by the profession, and is still very generally imagined by the vulgar, that unusual blackness or lividity of the skin, indicates death by poison generally. But every experienced physician is now well aware, that excessive lividity is by no means universally produced by poison, and that it is likewise produced by so many natural diseases as not even to form, in any circumstances whatever, the slightest ground of suspicion. ”

“ When the amount is too large to be dealt with by the leucocytes, poisoning seems to occur even in the most habituated. Tolerance is therefore analogous to, but not identical with, the immunity which takes place with the toxins of infectious diseases and snake poison. Certain substances, notably digitalis, lead, mercury and strychnine, exhibit what is called a cumulative action—that is to say, when small quantities have been taken over a period of time, poisoning or an excessive action suddenly ensues. ”

“ In a few diseased states of the system there is an increased susceptibility of the action of poisons: and it is important that the medical jurist should attend to this circumstance. When a poison has a tendency to bring on a peculiar pathological state of the system, or of a particular organ, which state is also produced by a disease existing at the time or impending, violent and even fatal consequences may ensue from doses of poisons which in ordinary circumstances are innocuous or beneficial. ”

“ We will simply state briefly here that a poison is anything which can not be used in the metabolism of the body and which, if allowed to remain in the body, will be carried to the tissue cells and do harm. In this event Innate will at once begin a process of elimination. If the channels of excretion are not normal and the organs are unable to do their work properly because of the interference with the transmission of mental impulses, it can readily be seen that the poison will be retained in the body and do harm. ”

“ Sometimes the poison attacks the throat, causing most destructive ulcerations therein; sometimes it seizes upon the nasal bones, resulting in their entire destruction and an awful disfiguration of the face; sometimes it ultimates itself in the ulceration and destruction of other osseous tissues in different portions of the body. Living examples of these facts are too frequently witnessed in the streets of any large city. Young men marrying with the slightest taint of this poison in the blood will surely transmit the disease to their children. ”

“ The power of the cellular tissue as a medium of absorption, has not been, and cannot easily be, ascertained. On the one hand it is difficult to apply poisons to it, without also applying them to the mouths of divided vessels; and, on the other hand, it is difficult to make a set of experiments for comparison with others on the stomach, pleura, or peritonæum, as the cellular tissue does not form an expanded cavity, and consequently, the extent of surface to which a poison is applied cannot be made the same in each experiment of a series. ”

“ The post-mortem appearances peculiar to the various poisons will be described in due course. Experiments on Animals.—These may be of value, but are not always conclusive. Chemical Analysis.—This is one of the most important forms of evidence, as a demonstration of the actual presence of a poison in the body carries immense weight. The poison may be discovered in the living person by testing the urine, the blood abstracted by bleeding, or the serum of a blister. In the dead body it may be found in the blood, muscles, viscera—especially the liver—and secretions. ”

“ After death the stomach is found to contain black extravasated blood, exactly like blood acted on by oxalic acid out of the body; the inner coat of the stomach is of a cherry-red colour, with streaks of black granular warty extravasation; and in some places the surface of the coat is very brittle and the subjacent stratum gelatinized, evidently by the chemical action of the poison. ”

“ It has been enumerated nevertheless among the general characters of poisoning, because, although its presence can hardly ever add any weight to the evidence in favour of death by poison, its absence may sometimes afford even positive proof in favour of natural death. That is, changes of a certain kind occurring in the symptoms during their progress may be incompatible with the known effects of a particular poison or of all poisons, and capable of being accounted for only on the supposition of natural disease having been at least the ultimate cause of death. ”

“ It has been noticed that, with great relaxation of the muscular system, the patients complain of every movement causing pain. With these general symptoms added to the local injury, death may follow many days after the swallowing of the fatal dose.
Death may also occur simply from the local injury done to the throat and larynx, and the patient may linger some time. Thus, in a case quoted by Taylor, [121] in which none of the poison appears actually to have been swallowed, the man died nineteen days after taking the poison from inflammation of the throat and larynx. ”

“ A common notion prevails that pounded glass is an active poison. There is no doubt, indeed, that it does possess some irritant properties even when finely pulverized; for it titillates and smarts the nostrils, and inflames the eyes. There is also little doubt that when swallowed in fragments of moderate size, especially if the stomach is empty, it may wound the viscera. But it is in this way only that it has any action when swallowed, and even then its effects are by no means uniformly serious. It can have no chemical action on the stomach ”

“ It is a striking fact in the action of that poison that, whatever be the texture in the body to which it is applied, provided death do not ensue quickly, it almost always produces symptoms of inflammation in the stomach; and on inspection after death traces of inflammation are found in that organ. In some instances of death caused by its outward application, the inflamed appearance of the stomach has been greater than in many cases where it had been swallowed. Sproegel met with a good example of this in a dog killed by a drachm applied to wounds. ”

“ In the ulceration produced by poisons there is generally speaking nothing to distinguish it from natural ulcers; but that caused by some poisons, such as iodine, is said to differ by the surrounding coloration of the membrane; and when the ulcer is caused by a sparingly soluble poison in a state of powder, such as arsenic, the cavity of the ulcer is sometimes filled with the powder. Perforation is a rare effect of the simple irritant poisons; but it is often caused by corrosives. It is imitated by two of the varieties of perforation from natural disease. ”

“ When the poison is administered by the stomach, death generally takes place between a period of five minutes and five-and-twenty minutes after the symptoms first make their appearance. I have frequently opened the bodies of animals thus killed, and have never been able to trace any effect of the poison upon the stomach or intestines, or upon the spinal cord or brain, that I could attribute satisfactorily to the poison. The heart of the animal generally contained blood in all the cases in which I have been concerned. In the case of the wild boar the poison was injected into the chest. ”

“ No morbid appearance could be detected in the body. The heart contracted vigorously for some time after death. These phenomena correspond in the main with what has been recorded of the symptoms caused by the roots in man.—Dr. Pereira informs me he had found the juice both of the root and leaves to act as a poison, either when introduced into the peritonæum, or when injected into the veins ”

“ The primary change of poles is, however, in the blood. Poisoning is a balancing of the blood-poles.
2592. Indifferent blood is no longer blood, but chyle or infusorial primary mass.
2593. The nutritive fluid or chyle is poisoned organic substance. There is no aliment except what is wrought by poison.
2594. The poisoning of the aliments must take place through the medium of their blood, or their sap. If poison therefore does not get into the blood, the death does not ensue. The digestive juice is poison only for the blood, but not for the other systems. ”

“ In the first place, in cases where a defence is attempted by a charge of imputation of poisoning it may be necessary to determine by an accurate account of the symptoms, or by the morbid appearances, or by both together, whether the poison was introduced into the body before or after death. For it is said, that attempts have been made to impute crime by introducing poison into the stomach or anus of a dead body ”

“ Poisons applied to the brain tissue, or to nerve trunks, do not produce symptoms, and the action of a poison may be arrested for a time by compressing by a ligature the main vessels of the limb under the skin of which the poison has been injected. After death no trace of the poison may be detected, the quantity taken being just sufficient to produce a fatal result, or elimination may be so rapid that, although death was directly due to the poison, any remains of its existence cannot be made out. ”

“ Supposing the poison to have been absorbed, what time would you give for the circulating process?—The circulation of the blood through the whole system is considered to take place about once in four minutes. The circulation in animals is quicker. The absorption of the poison by rabbits is therefore quicker. The time would also depend on the stomach,—whether it contained much food or not,—whether the poison came into immediate contact with the inner surface of the stomach. ”

“ In recent times the employment of chemical preservatives has acquired a new aspect through the increasing tendency of manufacturers to add to food products antiseptic chemicals in wide variety and of dubious physiological effect.
It is not so easy and simple as it might appear to declare that no substance that is poisonous shall be added to food. The scientific conception of a poison is one involving the amount as well as the kind of substance. Common salt itself is poisonous in large doses, but, as everyone knows, small amounts are not only not injurious, but absolutely necessary to health. ”

“ Though, after all, a single dose be not mortal, yet a quantity of poison, however small, when taken at every meal, must produce more fatal effects than are generally apprehended; and different constitutions are differently affected by minute quantities of substances that act powerfully on the system. ”

“ It may, however, be shortly said, that the most common changes are fatty infiltration of the liver and kidneys, fatty degeneration of the heart, enlargement of the liver, ecchymoses in the serous membranes, in the muscular, in the fatty, and in the mucous tissues. When death occurs before jaundice supervenes, there may be little in the aspect of the corpse to raise a suspicion of poison; but if intense jaundice has existed during life, the yellow staining of the skin, and it may be, spots of purpura, will suggest to the experienced pathologist the possibility of phosphorus poisoning. ”