Substance abuse involves the harmful or dangerous use of psychoactive substances, resulting in physical, psychological, or social damage. This issue has been examined through various perspectives, ranging from public health approaches that focus on societal influences to medical evaluations that classify it as a long-term condition. Political leaders such as George W.
Bush and Donald Trump emphasized its impact on society and the importance of rehabilitation programs, while research, including studies by Seena Fazel and colleagues, associated substance use disorders with heightened risks of violence. The evidence highlights substance abuse as a multifaceted interaction of personal susceptibility, environmental stressors, and structural obstacles, requiring comprehensive solutions.