Friedrich A. Flückiger

“ Description—The mace, separated from the seed by hand, is dried in the sun, thereby losing its brilliant red hue and acquiring an orange-brown colour. It has a dull fatty lustre, exudes oil when pressed with the nail, and is horny, brittle, and translucent. Steeped in water it swells rather considerably. The entire arillus, compressed and crumpled by packing, is about 13⁄4 inches long with a general thickness of about 1/20 of an inch or even at 1⁄10 the base. Mace has an agreeable aromatic smell nearly resembling that of nutmeg, and a pungent, spicy, rather acrid taste. ”

“ Description—The Bitter Orange known in London as the Seville Orange is a globular fruit, resembling in size, form, and structure the common Sweet Orange, but having the peel much rougher, and when mature of a somewhat deeper hue. The pulp of the fruit is filled with an acid bitter juice. The ripe fruit is imported into London; the peel is removed from it with a sharp knife in one long spiral strip, and quickly dried, or it is sold in the fresh state. It is the more esteemed when cut thin, so as to include as little as possible of the white inner layer. ”

“ It is nearly destitute of taste and smell, but an alcoholic solution poured into water emits a melon-like odour. Kamala is scarcely acted on by water, even at a boiling heat; on the other hand, alcohol, ether, chloroform or benzol extract from it a splendid red resin. Neither sulphuric nor nitric acid acts upon it in the cold, nor does oil of turpentine become coloured by it unless warmed. It floats on water, but sinks in oil of turpentine. When sprinkled over a flame, it ignites after the manner of lycopodium. Heated alone, it emits a slight aromatic odour ”

“ Production—In the south-west of India, the plant, or Pepper Vine as it is called, grows on the sides of the narrow valleys where the soil is rich and moist, producing lofty trees by which a constant, favourable coolness is maintained. In such places the pepper-vine runs along the ground and propagates itself by striking out roots into the soil. The natives tie up the end of the vines lying on the ground to the nearest tree, on the bark of which the stems put out roots so far as they have been tied, the shoots above that hanging down. ”

“ Adulteration and Substitution—Aconite root, though offered in abundance in the market, is by no means always obtained of good quality. Collected in the mountainous parts of Europe by peasants occupied in the pasturing of sheep and cattle, it is often dug up without due regard to the proper season or even to the proper species,—a carelessness not surprising when regard is had to the miserable price which the drug realizes in the market. ”

“ When well prepared, Banbury rhubarb is of excellent appearance. The finest pieces, which are semi-cylindrical, are quite equal in size to the drug of China. The colour is as good, and the fractured surface exhibits pink markings not less distinct and brilliant. Even the smaller roots, which are dried as sticks, have internally a good colour, and afford a fine powder. But the odour is somewhat different from that of Chinese rhubarb; the taste is less bitter but more mucilaginous and astringent, and the root is of a more spongy, soft, and brittle texture. ”

“ Bitter almond oil, which by oxidation yields benzoic acid, is wanting in benzoin. Very little volatile oil is in fact to be got; half a pound of the best Penang benzoin yielded us by distillation with water only a few drops of an extremely fragrant oil (styrol?) .
Ferric chloride imparts to an alcoholic solution of benzoin a dark brownish green, which is not acquired under the same circumstances by the aqueous decoction of the powdered resin. Benzoin dissolves in cold oil of vitriol, forming a solution of splendid carmine hue, from which water separates crystals of benzoic acid. ”

“ If the leaves are examined under alcohol or almond oil the colourless layer is seen to be very narrow, and the thin walls of its cells shrunken and not clearly distinguishable. If the transverse sections are examined under water, these cells immediately swell up, and become strongly distended, giving off an abundance of mucilage, the latter being afforded by the solution of the very cell-walls. The mucilage of buchu leaves thus originates in the same way as in flax seed or quince seed, but in the former the epidermis is thrown off without alteration. ”

“ Scammony is very extensively adulterated. The adulteration is often performed by the peasants, who mix foreign substances into the drug while it is yet soft; and it is also effected by the dealers, some of whom purchase it of the peasants in a half-dried state. The substances used for sophistication are numerous, the commonest and most easily detected being, according to our experience, carbonate of lime and flour. Woodashes, earth (not always calcareous) , gum arabic, and tragacanth are also employed; more rarely, wax, yolk of egg, pounded scammony roots, rosin, or black-lead. ”

“ In texture, the barks vary in an important manner by reason of diversity in anatomical structure. Their fracture especially depends upon the number, size, and arrangement of the liber-fibres, as will be shown in our description of their microscopic characters.
The taste in all species is bitter and disagreeable, and in some there is in addition a decided astringency. Most species have no marked odour, at least in the dried state. ”

“ So great is its power of absorbing water that even with 50 times its weight, it forms a thick mucilage. If one part of tragacanth is shaken with 100 parts of water and the liquid filtered, a neutral solution may be obtained which yields an abundant precipitate with acetate of lead, and mixes clearly with a concentrated solution of ferric chloride or of borax,—in these respects differing from a solution of gum arabic. On the other hand, it agrees with the latter in that it is thrown down as a transparent jelly by alcohol, and rendered turbid by oxalate of ammonium. ”

“ Adulteration—No drug is more subject than attar of rose to adulteration, which is principally effected by the addition of the volatile oil of an Indian grass, Andropogon Schœnanthus L. This oil, which is called in Turkish Idris yàghi, and also Entershah, and is more or less known to Europeans as Geranium Oil, is imported into Turkey for this express purpose, and even submitted to a sort of purification before being used. ”

“ European Opium—From numerous experiments made during the present century in Greece, Italy, France, Switzerland, Germany, England, and even in Sweden, it has been shown that in all these countries a very rich opium, not inferior to that of the East, can be produced.
The most numerous attempts at opium-growing in Europe have been made in France. But although the cultivation was recommended in the strongest terms by Guibourt, [219] who found in French opium the highest percentage of morphine yet observed (22·8 per cent.) , it has never become a serious branch of industry. ”

“ The epidermis, in the anatomical sense, occurs only in the youngest barks, which are not found in commerce. The corky layer, which replaces the epidermis, is constructed of the usual tabular cells. In some species as C. Calisaya, it separates easily, at least in the older bark, whereas in others as C. succirubra, the bark even of trunks is always coated with it. In several species the corky tissue is not only found on the surface, but strips of it occur also in the inner substance of the bark. ”

“ After an almond has been macerated in warm water, the skin is easily removed, bringing with it the closely attached translucent inner membrane or endopleura. As the seed is without albumen, the whole mass within the testa consists of embryo. This is formed of a pair of plano-convex cotyledons, within which lie the flat leafy plumule and thick radicle, the latter slightly projecting from the pointed or basal end of the seed.
Almonds have a bland, sweet, nutty flavour. When triturated with water, they afford a pure white, milk-like emulsion of agreeable taste. ”

“ In some villages it is the practice to make the masses larger than in others. Before the opium is ready for the market, a meeting of buyers and sellers is held in each district, at which the price to be asked is discussed and settled,—the peasants being most of them in debt to the buyers or merchants.
To the latter the opium is sold in a very soft but natural state. These dealers sometimes manipulate the soft drug with a wooden pestle into larger masses which they envelope in poppy leaves and pack in cotton bags sealed at the mouth for transport to Smyrna. ”

“ Botanical Origin—Papaver Rhœas L.—The common Red Poppy or Corn Rose is an annual herb found in fields throughout the greater part of Europe often in extreme abundance. It almost always occurs as an accompaniment of cereal crops, frequently disappearing when this cultivation is given up. It is plentiful in England and Ireland, but less so in Scotland; is found abundantly in Central and Southern Europe and in Asia Minor, whence it extends as far as Abyssinia, Palestine, and the banks of the Euphrates. But it does not occur in India or in North America. ”

“ Theophrastus and Nicander give the castor oil plant the name of Κρότων. Dioscorides, who calls it Κίκι or Κρότων, describes it as of the stature of a small fig-tree, with leaves like a plane, and seeds in a prickly pericarp, observing that the name Κρότων is applied to the seed on account of its resemblance to an insect [Ixodes Ricinus Latr.] , known by that appellation. He also gives an account of the process for extracting castor oil (Κίκινον ἔλαιον) , which he says is not fit for food, but is used externally in medicine; he represents [Pg 568] the seeds as extremely purgative. ”

“ Microscopic Structure—The hairs of nux vomica are of remarkable structure. They are formed as usual of the elongated cells of the epidermis, and have their walls thickened by secondary deposits, which are interrupted by longitudinally extended pores; they are a striking object in polarized light. The albumen is made up of large cells, loaded with albuminoid matters and oily drops, but devoid of starch. In water the thick walls of this parenchyme swell up and yield some mucilage; the cotyledons are built up of a narrow, much more delicate tissue, traversed by small fibro-vascular bundles. ”

“ The roots proper, which diminish in size down to the thickness of a quill, are covered with a dull, rough, spongy bark. This bark has an inert, soft corky layer, beneath which is a firmer inner bark of brighter hue, rich in essential oil. The wood of the root is light and easily cut, in colour of a dull reddish-brown, and with a fragrant odour and spicy taste similar to that of the bark but less strong. It is usually sold in the shops rasped into shavings. ”

“ The hard and heavy wood which is so bitter that no insect will attack it, the medicinal leaves and bark, the fruit which affords an acrid bitter oil used in medicine and for burning, the gum which exudes from the stem, and finally a sort of toddy obtained from young trees, cause the Nim to be regarded as one of the most useful trees of India. ”

“ Usually the peasant does not dry off the juice promptly, but allows his daily gatherings to accumulate; and when he has collected a pound or two, he places it in the sunshine to soften, and then kneads it, sometimes with the addition of a little water, into a plastic mass, which he lastly allows to dry. By this long exposure to heat, and retention in a liquid state, the scammony juice undergoes fermentation, acquires a strong cheesy odour and dark colour, and when finally dried, exhibits a more or less porous or bubbly structure, never observable in shell scammony. ”

“ When liquid storax is heated, it becomes by the loss of water dark brown and transparent, the solid impurities settling to the bottom. Spread out in a very thin layer, it partially dries, but does not wholly lose its stickiness. When free from water (which reddens litmus) it dissolves in alcohol, spirit of wine, chloroform, ether, glacial acetic acid, bisulphide of carbon, and most of the essential oils, but not in the most volatile part of petroleum (“petroleum ether”) . ”

“ Respecting the colouring matter and an extremely small quantity of a volatile body with pepper-like odour, we know but little. After the colouring matter has been precipitated from an aqueous solution of opium by lead acetate, the liquid becomes again coloured by exposure to the air. As to the volatile body, it may be removed by acetone or benzol, but has not yet been isolated.
The salts of inorganic bases, chiefly of calcium, magnesium and potassium, contain partly the ordinary acids such as phosphoric and sulphuric, and partly an acid peculiar to the poppy. ”

“ The mucilage of carrageen, like many similar bodies, obstinately retains inorganic matter; after it had three times been dissolved in water, and as many times precipitated with alcohol, we found it still to yield the same quantity of ash as the raw drug itself, that is to say, more than 15 per cent. The mucilage, perfectly dried, is a tough horny substance, of a greyish colour; it quickly swells up in water, forming a jelly which is precipitable by neutral acetate of lead. ”

“ As the druggist has to purchase linseed meal, he must of necessity rely to some extent on the character of the oil-presser from whom he derives his supplies. The presence of the seeds of Cruciferæ (as rape and mustard) which is common, may be recognized by the pungent odour of the essential oil which they develope in contact with water. The introduction of cereals would also be easily discovered by iodine, which strikes no blue colour in a decoction of linseed. The microscope will also afford important aid in the examination of linseed cake or meal. ”

“ In the price-currents of commercial houses in China three sorts of sandal-wood are enumerated, namely, South Sea Island, Timor, and Malabar; the last fetches three or four times as high a price as either of the others. Even the Indian sandal-wood may vary in an important manner. Beddome, [2264] conservator of forests in Madras, and an excellent observer, remarks that the finest sandal-wood is that which has grown slowly on rocky, dry and poor land; and that the trees found in a rich alluvial soil, though of very fine growth, produce no heartwood and are consequently valueless. ”

“ Adulteration—Essence of bergamot, like that of lemon, is extensively and systematically adulterated, and very little is sent into the market entirely pure. It is often mixed with oil of turpentine, but a finer adulteration is to dilute it with essential oil of the leaves or with that obtained by distillation of the peel or of the residual fruits. Some has of late been adulterated with petroleum. ”

“ Masticated they have for an instant a bitterish taste which however quickly becomes pungent. When triturated with water they afford a yellowish emulsion emitting a pungent acrid vapour which affects the eyes, and has a strong acid reaction. The seeds powdered dry have no such pungency. When the seeds are triturated with solution of potash, the pungent odour is not evolved; nor when they are boiled in water. Neither is the acridity developed on triturating them with alcohol, dilute mineral acids, or solution of tannin, or even with water when they have been kept in powder for a long time. ”

“ Schoonbroodt [2737] performed some interesting experiments with fresh fern root, showing that it contains volatile acids of the fatty series, among which is probably formic; but also a fixed acid, accompanied by an oil of disagreeable odour. The liquid distilled from the dried root did not evolve a similar odour, nor did it contain any acid body. A small quantity of essential oil was obtained by means of ether from the alcoholic extract of the fresh but not of the dried rootstock. The rhizome of male fern yields 2 to 3 per cent. ”

“ Oil of turpentine, like volatile oils in general, undergoes on exposure to the air certain alterations giving rise to what is called resinification. The formic acid which is produced in small quantity during this change characterizes it as one of oxidation; the chief products however are not exactly known, and not one of them has been proved identical with any natural resin. The common assumption that resins are produced from volatile oils by simple oxidation, is consequently not yet entirely justified. ”

“ After a tree is 8 years old and when its stem is at least 3 inches in thickness, the gathering of manna may begin; and may continue for 10 or 12 years, when the stem is usually cut down, and a young one brought up from the same root takes its place. The same stump thus has often two or three stems rising from it.
To obtain manna, transverse cuts from 11⁄2 to 2 inches long and 1 inch apart, are made in the bark, just reaching to the wood. One cut is made daily, beginning at the bottom of the tree, the second directly above the first, and so on while dry weather lasts. ”

“ History—Much as roses were prized by the ancients, no preparation such as rose water or attar of rose was obtained from them. The liquid that bore the name of Rose Oil (ῤόδινον ἔλαιον) is stated by Dioscorides [1002] to be a fatty oil in which roses have been steeped. In Europe a similar preparation was in use down to the last century, Oleum rosarum, rosatum or rosaceum, signifying an infusion of roses in olive oil in the London Pharmacopœia of 1721. ”