Colocynth

Definition and stakes

Friedrich A. Flückiger,  Pharmacographia (1879)

“ Walz thus obtained about 1⁄4 per cent. of a yellowish mass or tufts, which he considered as possessing crystalline structure and to which he gave the name Colocynthin. He assigns to it the formula C56H84O23, which in our opinion requires further investigation. Colocynthin is a violent purgative; it is decomposed according to Walz by boiling dilute hydrochloric acid, and then yields Colocyntheïn, C44H64O13, and grape sugar. The same chemist termed Colocynthitin that part of the alcoholic extract of colocynth which is soluble in ether but not in water. ”
Source: Gutenberg

1911 Encyclopædia Britannica, Volume 6… (1911)

“ In ordinary doses it greatly increases the secretion of the small intestine and stimulates its muscular coat. The gall-bladder is also stimulated, and the biliary function of the liver, so that colocynth is both an excretory and a secretory cholagogue. The action which follows hypodermic injection is due to the excretion of the drug from the blood into the alimentary canal. Though colocynth is a drastic hydragogue cathartic, it is desirable, as a rule, to supplement its action by some drug, such as aloes, which acts on the large intestine, and a sedative must always be added. ”
Source: Wikisource

Sir Robert Christison,  Treatise on Poisons

“ It is imported into this country in the form of a roundish, dry, light fruit, as big as an orange, of a yellowish-white colour, and excessively bitter taste. Its active principle is probably a resinoid matter discovered by Vauquelin, which is very soluble in alcohol and sparingly so in water, but which imparts even to the latter an intensely bitter taste. [1437] It is termed Colocynthin.
According to the experiments of Orfila, colocynth powder or its decoction produces the usual effects of the acrid vegetables on the stomach and on the subcutaneous cellular tissue.
”
Source: Gutenberg

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