Paul Ehrlich

“ Bearing in mind that polynuclear neutrophil cells are developed and stored up only in the bone-marrow, that in ordinary leucocytosis only the polynuclear forms are increased in the blood-stream, it is evident that leucocytosis is purely a function of the bone-marrow, as Ehrlich has always insisted with all distinctness. ”

“ On the grounds of this observation Ehrlich returned to his original assumption that the granules are secretory products of the cells, and defined his standpoint at that time as follows:
"Did the neutrophil granulations really represent the bodies which supply these cells with oxygen, as Altmann supposes, a condition such as we have here brought [Pg 130] forward would be impossible, since with the disappearance of the granules death of the cells must follow. But from the point of view of the secretion theory the condition described is easily explainable. ”

“ The chief characteristic is, as Ehrlich has always particularly insisted, the constitution of the nucleus. The nuclei of cells which are with certainty to be reckoned among the normoblasts are marked by the absence of structure, their sharply defined contour, their intense affinity for nuclear stains. That is by properties which histology sums up under the name Pyknosis (Pfitzner) and recognises as signs of old age. The nuclei of the megaloblasts are round, shew a good deal of structure, and stain far less deeply. ”

“ These have played an important part in general histology, from the time that they were first introduced by Ehrlich into the histology of the blood up to the present day; and deserve before all others a full consideration.
Neutral staining rests on the fact, that nearly all basic dyes (i.e. salts of the dye bases, for instance, rosanilin acetate) form combinations with acid dyes (i.e. salts of the dye acids, for instance, ammonium picrate) which are to be regarded as neutral dyes, such as rosanilin picrate. ”

“ Our knowledge of eosinophil leucocytosis is still of comparatively recent date. After Ehrlich demonstrated the constant increase of the eosinophil cells in leukæmia a considerable time elapsed before an eosinophilia was found in other diseases, an eosinophilia however that differs in its essential traits from the leukæmic type. To Friedrich Müller we owe the first researches in this direction, at whose suggestion Gollasch investigated the blood of persons suffering from asthma; in which he was able to demonstrate a considerable increase of the eosinophil cells. ”

“ With the abundant information, the well argued deductions and the carefully drawn up statement here placed before us it may be claimed that we are now in a position to make diagnoses that not long ago were quite beyond our reach, whilst a thorough training of our younger medical men in the methods of blood examination must result in the accumulation of new facts of prime importance both to the pathologist and to the physician. ”

“ Quite recently Pappenheim, partly in conjunction with O. Israel, has carried out very thorough researches on these particular points. As the subject for observation he chose the blood of embryonic mice. He was able in the first place, like Rindfleisch, to produce the exit of the nuclei from the cells by the addition of "physiological" salt solution to fresh blood, and is of the opinion that the exit of the nucleus from the erythroblasts only takes place artificially. ”

“ The importance Altmann ultimately gave to the granules, which he also calls by the name "Ozonophores" is shewn by his own words (Elementary Organisms, 1st edit., p. 39) :
"Our conception of the ozonophores may therefore replace that of the living protoplasm, at least so far as vegetative function is concerned; and may serve us as an explanation of complicated organic processes. ”

“ One expression of these distant actions is, as Leichtenstern insists, the eosinophilia of the blood. We do not think we should assume on the evidence before us, that the substance which attracts the eosinophil cells is identical with the cause of the anæmia. Many observations, the absence, for example, of eosinophilia in Bothriocephalus anæmia (Schauman) , render probable the existence of two different functions. In any case the substance causing the eosinophilia is more widely distributed than that to which the anæmic condition is due.
Leukæmia. ("Mixed leucocytosis.") ”

“ Climatic conditions apparently exercise a great influence over the number of corpuscles. This fact is important for physiology, pathology, and therapeutics, and has come to the front especially in the last few years, since Viault's researches in the heights of the Corderillas. As his researches, as well as those of Mercier, Egger, Wolff, Kœppe, v. Jaruntowski and Schrœder, Miescher, Kündig and others, shew, the number of red blood corpuscles in a healthy man, with the normal average of 5,000,000 per mm.3, begins to rise immediately after reaching a height considerably above the sea-level. ”

“ Under Koch's inspiration and guidance and in the same institute many great scientific discoveries of incalculable value to humanity were made. Foremost among them are the works of Ehrlich, one of Koch's most celebrated pupils, who recently gave to the world a new remedy which promises to prove a specific in an affliction from which mankind has suffered for centuries. ”

“ To Madeline, Gottlieb was a wicked old man who made fun of the sanctities of Marriage and Easter lilies, to Clif, he was a bore, but Leora glowed as Martin banged the table and quoted his idol: “Up to the present, even in the work of Ehrlich, most research has been largely a matter of trial and error, the empirical method, which is the opposite of the scientific method, by which one seeks to establish a general law governing a group of phenomena so that he may predict what will happen.” ”

“ Well—these darn' studes, they aren't trying to learn science; they're simply learning a trade. They just want to get the knowledge that'll enable them to cash in. They don't talk about saving lives but about 'losing cases'—losing dollars! And they wouldn't even mind losing cases if it was a sensational operation that'd advertise 'em! They make me sick! How many of 'em do you find that're interested in the work Ehrlich is doing in Germany—yes, or that Max Gottlieb is doing right here and now! ”

“ Hence it is that Emerson often loses value for his admirers in proportion to their maturity and experience. He is above all the poet of religion and philosophy for the young; whereas men, as they grow older, are inclined to turn from him, in their more serious moods, to those sages who have supplemented insight with a firm grasp of the darker facts of human nature. That is undoubtedly true; nevertheless, as time passes, the deficiencies of this brief period of New England, of which Emerson was the perfect spokesman, may well be more and more condoned for its rarity and beauty. ”

“ But though I was initially disappointed at being categorized as an extremist, as I continued to think about the matter I gradually gained a measure of satisfaction from the label. Was not Jesus an extremist for love: "Love your enemies, bless them that curse you, do good to them that hate you, and pray for them which despitefully use you, and persecute you." Was not Amos an extremist for justice: "Let justice roll down like waters and righteousness like an ever flowing stream." Was not Paul an extremist for the Christian gospel: "I bear in my body the marks of the Lord Jesus." ”

“ When dinner was over she went with her husband for a walk upon the deck until the cold drove them to the saloon, where she was soon the center of interest to the Colonel’s New York friends, who vied with each other in paying her attention. Matters were not so bad after all, and it was a pretty good thing to be the bride of a man as rich and well known as Col. Errington. Jack and The Elms and Annie and Katy and Paul began to grow misty and far away from this gay company of polished city people. ”

“ Emerson’s philosophy is thus a kind of reconciled dualism, and a man’s attitude towards it in the end will be determined by his sense of its sufficiency or insufficiency to meet the facts of experience. One of Emerson’s biographers has attempted to set forth this philosophy as “a synthesis and an anticipation.” ”

“ At the present time, however, Ehrich is a bona fide student at the Harvard school, he is within the age limit required by the I.S.A.A., he has never "attended any college," in the sense conveyed by the rules of the I.S.A.A., and he has [Pg 490] never been in business. It seems therefore that he should be allowed to ride without protest, so long as there is no direct legislation affecting the case.
Baseball is in a much more nourishing state of activity in New England than it is in New York, although the N.Y.I.S.B.B. League games have been under way here for two weeks or more. ”

“ A week later, the court removed to Earl Paul’s palace at Orphir. We can picture the joyful meeting of the lovers; the uneasiness of Harold, whose jealousy was again aroused; and the revengeful thoughts of Fraukirk and Helga as they waited for the fatal web. It came at length, borne by the Dwarf’s raven, and the two women, rejoicing in their evil work, proceeded to cut out the vest with which they hoped to effect the destruction of Earl Paul. ”

“ But it seems equally true that the coming man who shall resolve our will never content himself with a universe a-tilt, a universe in cascade, so to speak; the craving for permanence in some form cannot be jauntily evaded. Is there any known mind which foreshadows the desired combination so clearly as Emerson’s? Who has felt profoundly the evanescence and evasiveness of things?... Yet Emerson was quite as firm in his insistence on a single unalterable reality as in his refusal to believe that any aspect or estimate of that reality could be final. ”

“ Ehret die Frauen! Sie stricken und weben / Wollene Strümpfe fürs frostige Leben—Honour to the women! they knit and weave worsted stockings for our frosty life. Volkswitz.
Ehrlich währt am längsten—Honesty lasts 25 longest. Ger. Pr.
[Greek: Ei de theon anêr tis elpetai lathemen / Erdôn, hamartanei] —If any man hopes that his deeds will pass unobserved by the Deity, he is mistaken. Pindar.
Eident (diligent) youth makes easy age. Sc. Pr.
Eifersucht ist eine Leidenschaft, die mit Eifer sucht was Leiden schafft—Jealousy is a passion which seeks with zeal what yields only misery. ”

“ Those who lived beneath that lowly roof were nowhere to be seen. Generally at this time of the day, everyone dozed over some slight work, so Everhard was much surprised when he saw the door of the house open, and a perfect stranger step out into the bright sunshine. He was a tall young man dressed in a light summer costume. His face was partly shaded by a broad brimmed straw-hat, and only a fair moustache of a military cut was visible underneath it. ”

“ I could tell you a hundred traits of her excellent disposition. I have often felt anxious about her, for so precocious a tenderness of feeling is said to be the presage of a short life. Who can tell whether it may not be realized."
Everhard looked out on the lake, and seemed not to have heard her last words. Suddenly he said; "you have probably a portrait of your husband: Will you show it to me?"
She took off a delicately worked Venetian chain, which she wore round her neck, opened the locket which was fastened to it, and handed it to him. ”

“ Where they fail to reach the reader’s heart, it is not because they are fundamentally disjointed, as if made up of sentences jostled together like so many mutually repellent particles; but because from the manner of his composition Emerson often missed what he might have learned from Plato’s Phaedrus was the essence of good rhetoric, that is to say, the consciousness of his hearer’s mind as well as of his own. ”

“ Believest thou not in men around whom floats the mountain air of a higher position, and who up on their height stand in the midst of a still heaven, and look down into the thunders and rainbows near the earth? Believest thou not in a God, and seekest thou not his thoughts in the lineaments of nature, and his eternal love in thy breast? ”

“ The necessity of the dualism that underlies Emerson’s philosophy could scarcely be put more neatly, and the kind of synthesis, or reconciliation, in which Emerson floated is admirably expressed. But it is not so plain that this synthesis anticipates the solution of the troublesome problems of life. There will be those who will ask whether the power of religion for mature minds does not depend finally on its feeling for evil. How otherwise, in fact, shall religion meet those harder questions of experience when its aid is most needed? ”

“ Ehrich did not write this himself, but whether he did or not, the statement is certainly not published without his knowledge and consent, and he is consequently severely censurable for such an expression of opinion. It is contrary to the spirit of amateurism, it is harmful to the best interests of honesty in school sport, and [Pg 198] it is insidious in that it may lead younger boys to believe that such statements are just and correct. ”

“ Like a daring goddess, she bent her firm, smooth brow, her dark eye, and the rose-blossoms of her countenance upon the adder's head, which Nature had trodden flat, and played with it close to her breast. ”

“ He can accept nothing as fact that tells against his dogma. His optimism becomes a bigotry, and, though of a nobler typethan the common American conceit of the preeminent excellence of American things as they are, has hardly less of the quality of fatalism. To him this is the best of all possible worlds, and the best of all possible times. He refuses to believe in disorder or evil.... But such inveterate and persistent optimism, though it may show only its pleasant side in such a character as Emerson’s, is dangerous doctrine for a people. ”