Edward Jenner

“ Compare English Bards, etc., lines 131, 132—
"What varied wonders tempt us as they pass!
The Cow-pox, Tractors, Galvanism, and Gas."
See Poetical Works, 1898, i. 307, note 3.]
[64] [Edward Jenner (1749-1823) made his first experiments in vaccination, May 14, 1796. Napoleon caused his soldiers to be vaccinated, and imagined that the English would be gratified by his recognition of Jenner's discovery.
Sir William Congreve (1772-1828) invented "Congreve rockets" or shells in 1804. They were used with great effect at the battle of Leipzig, in 1813.] ”

“ It is to a "country doctor" that England and the world owe one of the greatest benefits that modern medical science has conferred on the race, in the practice of vaccination. The youngest son of a Gloucestershire clergyman, Edward Jenner was placed, about 1763, as apprentice to a surgeon at Sodbury; and it was there, it is stated, that first the possibility of arresting the then dreaded and dreadful ravages of small-pox entered his mind. ”

“ In the apartments, which are mostly low, dark, and void of proportion, are preserved a numerous assemblage of portraits, chiefly of the Stratton branch, the bequest of the last heir of that family. Besides these portraits, here are several miniatures of the Berkeleys, of considerable antiquity, and so far curious. A few landscapes, by Wouvermans, Claude, Salvator Rosa, &c. complete the Berkeley collection. Edward Jenner, an English physician, celebrated for having introduced the practice of vaccination, as a preventive of the small-pox, Edward Jenner. ”

“ It was a triumph of experimental science. The discoverer was no novice in scientific investigation, but a trained observer, who had served a long apprenticeship in scientific observation under no less a scientist than the celebrated John Hunter. At the age of twenty-one Jenner had gone to London to pursue his medical studies, and soon after he proved himself so worthy a pupil that for two years he remained a member of Hunter's household as his favorite pupil. ”

“ It is difficult for us of to-day clearly to conceive the greatness of Jenner's triumph, for we can only vaguely realize what a ruthless and ever-present scourge smallpox had been to all previous generations of men since history began. ”

“ The Royal Jennerian Society having failed, the national vaccine establishment was founded, for the extension of vaccination, in 1808. Jenner spent five months in London for the purpose of organizing it, but was then obliged, by the dangerous illness of one of his sons, to return to Berkeley. He had been appointed director of the institution; but he had no sooner left London than Sir Lucas Pepys, president of the college of physicians, neglected his recommendations, and formed the board out of the officials of that college and the college of surgeons. ”

“ Jones on the Composition of the Eau Medicinale d'Husson,' a quack medicine which he had discovered to consist of a spirituous solution of hellebore and opium. He published in 1815 'A History of the Smallpox,' dedicated to Edward Jenner, and in 1817 The History and Practice of Vaccination.' He had in 1809 communicated to the Medical and Chirurgical Society a paper 'On Gouty Concretions or Chalk Stones' (Transactions, i. 112) , and seems to have paid much attention to chemistry. ”

“ THE Paupers of the village of Tortworth, in this county, were inoculated by Mr. Henry Jenner, Surgeon, of Berkeley, in the year 1795. Among them, eight patients presented themselves who had at different periods of their lives had the Cow Pox. ”

“ May it not then be reasonably conjectured that the source of the smallpox is morbid matter of a peculiar kind, generated by a disease in the horse, and that accidental circumstances may have again and again arisen, still working new changes upon it until it has acquired the contagious and malignant form under which we now commonly see it making its devastations amongst us? ”

“ In the present age of scientific investigation, it is remarkable that a disease of so peculiar a nature as the Cow Pox, which has appeared in this and some of the neighbouring counties for such a series of years, should so long have escaped particular attention. ”

“ It is very apt to appear also when they are suckling their young. But this disease is not to be considered as similar in any respect to that of which I am treating, as it is incapable of producing any specific effects on the human constitution. ”

“ As it is not the identical matter inserted which is absorbed into the constitution, but that which is, by some peculiar process in the animal economy, generated by it, is it not probable that different parts of the human body may prepare or modify the virus differently? ”

“ And, from a consideration of the change which the infectious matter undergoes from producing a disease on the cow, may we not conceive that many contagious diseases, now prevalent among us, may owe their present appearance not to a simple, but to a compound origin? ”

“ There are certainly more forms than one, without considering the common variation between the confluent and distinct, in which the smallpox appears in what is called the natural way. About seven years ago a species of smallpox spread through many of the towns and villages of this part of Gloucestershire: it was of so mild a nature that a fatal instance was scarcely ever heard of, and consequently so little dreaded by the lower orders of the community that they scrupled not to hold the same intercourse with each other as if no infectious disease had been present among them. ”

“ It is curious also to observe that the virus, which with respect to its effects is undetermined and uncertain previously to its passing from the horse through the medium of the cow, should then not only become more active, but should invariably and completely possess those specific properties which induce in the human constitution symptoms similar to those of the variolous fever, and effect in it that peculiar change which for ever renders it unsusceptible of the variolous contagion. ”

“ A young woman who had the cow-pox to a great extent, several sores which maturated having appeared on the hands and wrists, slept in the same bed with a fellow-dairymaid who never had been infected with either the cow-pox or the smallpox, but no indisposition followed. ”

“ It is a remarkable fact, and well known to many, that we are frequently foiled in our endeavours to communicate the Small Pox by inoculation to blacksmiths, who in the country are farriers. They often, as in the above instance, either resist the contagion entirely, or have the disease anomalously. ”

“ The deviation of man from the state in which he was originally placed by nature seems to have proved to him a prolific source of diseases. From the love of splendour, from the indulgences of luxury, and from his fondness for amusement he has familiarised himself with a great number of animals, which may not originally have been intended for his associates.
The wolf, disarmed of ferocity, is now pillowed in the lady's lap. [1] The cat, the little tiger of our island, whose natural home is the forest, is equally domesticated and caressed. ”

“ For example, is it difficult to imagine that the measles, the scarlet fever, and the ulcerous sore throat with a spotted skin have all sprung from the same source, assuming some variety in their forms according to the nature of their new combinations? ”

“ It is an excess in the number of pustules which we chiefly dread in the smallpox; but in the cow-pox no pustules appear, nor does it seem possible for the contagious matter to produce the disease from effluvia, or by any other means than contact, and that probably not simply between the virus and the cuticle; so that a single individual in a family might at any time receive it without the risk of infecting the rest or of spreading a distemper that fills a country with terror. ”

“ I have been informed from respectable authority that in Ireland, although dairies abound in many parts of the Island, the disease is entirely unknown. The reason seems obvious. The business of the dairy is conducted by women only. Were the meanest vassal among the men, employed there as a milker at a dairy, he would feel his situation unpleasant beyond all endurance. ”

“ Case IX.—Although the cow-pox shields the constitution from the smallpox, and the smallpox proves a protection against its own future poison, yet it appears that the human body is again and again susceptible of the infectious matter of the cow-pox, as the following history will demonstrate. ”

“ The appearance of the disease in the spring and the early part of the summer, when they are disposed to be affected with spontaneous eruptions so much more frequently than at other seasons, induces me to think that the virus from the horse must be received upon them when they are in this state, in order to produce effects: experiments, however, must determine these points. But it is clear that when the cow-pox virus is once generated, that the cows cannot resist the contagion, in whatever state their nipples may chance to be, if they are milked with an infected hand. ”

“ February the 13th, 1797, I availed myself of an opportunity of inoculating William Rodway, the servant man above alluded to. Variolous matter was inserted into both his arms; in the right by means of superficial incisions, and into the left by slight punctures into the cutis. ”

“ Case VI.—It is a fact so well known among our dairy farmers that those who have had the smallpox either escape the cow-pox or are disposed to have it slightly, that as soon as the complaint shews itself among the cattle, assistants are procured, if possible, who are thus rendered less susceptible of it, otherwise the business of the farm could scarcely go forward. ”

“ Indeed it becomes almost a criterion by which we can determine whether the infection will be received or not. It seems as if a change, which endures through life, had been produced in the action, or disposition to action, in the vessels of the skin; and it is remarkable too, that whether this change has been effected by the Small Pox, or the Cow Pox, that the disposition to sudden cuticular inflammation is the same on the application of variolous matter. ”

“ Abraham Riddiford, a farmer at Stone in this parish, in consequence of dressing a mare that had sore heels, was affected with very painful sores in both his hands, tumours in each axilla, and severe and general indisposition. A surgeon in the neighbourhood attended him, who knowing the similarity between the appearance of the sores upon his hands and those produced by the cow-pox, and being acquainted also with the effects of that disease on the human constitution, assured him that he never need to fear the infection of the smallpox ”

“ One of them, Hester Walkley, I attended with that disease when she lived in the service of a Farmer in the same village in the year 1782; but neither this woman, nor any other of the patients who had gone through the Cow Pox, received the variolous infection either from the arm or from mixing in the society of the other patients who were inoculated at the same time. This state of security proved a fortunate circumstance, as many of the poor women were at the same time in a state of pregnancy. ”

“ It was the doctor's practice to make as slight an incision as possible upon the skin, and there to lodge a thread saturated with the variolous matter. When his patients became indisposed, agreeably to the custom then prevailing, they were directed to go to bed and were kept moderately warm. Is it not probable then, that the success of the modern practice may depend more upon the method of invariably depositing the virus in or upon the skin, than on the subsequent treatment of the disease? ”

“ Now they were green, and anon red or blue; now purple, and then ghastly white; ever and again, as the lightning flashed forth, this infernal face came out of the gloom with a diabolical grotesqueness, and a strange smile on it that appalled us all; and now another day began to break.
"'Mate, that fellow is more like a devil than a human being,' whispered Bob Jenner to me, echoing my own thoughts, as we clung together to the belaying pins abaft the mainmast.
"He spoke in a low whisper; but in an instant the eyes of Urbain were on him. ”