Medical experimentation

“ Disease is studiously propagated. Myriads of healthy living creatures are filled with loathsome disease in order to furnish ‘material’ for experimentation. So many kilos of dog or rabbit (used for injecting disease, or noted as more or less slowly resisting the death thus gradually inflicted) is a common expression now used in experimentation, and supposed to give ‘scientific accuracy’ to experiments. ”

“ It enables us to measure the growth of experimentation in England, not only from 1862 to 1876, when the present Cruelty to Animals Bill was enacted, but it also forms a point of comparison for testing the increase of vivisectional methods since 1876 to the present day, when these easy but often fallacious methods of research have become universal in medical investigation and medical instruction. ”

“ It is not through the torment of living creatures, not through the limitless sacrifice of laboratory victims, not through the utilization of babes as "material" for research, that medical science will yet achieve for humanity its greatest boon,—the prevention of disease. ”

“ I. Justifiable Experimentation upon Man
1. All experiments made by intelligent and conscientious physicians or surgeons upon their patients for some definite purpose pertaining to the personal benefit of the patient himself, and when practicable, in case of risk, with his or her consent. (This rule is intended to include every possible experiment made by a medical practitioner for the benefit of the patient, with a distinct ameliorative purpose in view.) ”

“ The greatest prizes in the lottery of physiological and pathological discovery have involved little or no pain. But the usual and staple work of a so-called `laboratory of vivisection, physiology or pathology,' for the education and practice of medical students in the unrestricted cutting of living animals, and for the indiscriminate and endless repetition of experiments already tried, where a live dog can be bought and its living nerves dissected, ... ”

“ He dies because, being a man, his [Pg 40] nervous system reacts in a different way from that of the dog or the rabbit. Do not count in any way upon the teachings of physiologists in practical matters. Don’t let your patient see any preparations, give the chloroform slowly, wait till he is profoundly asleep. That is all you can do.’
Again, at another discussion at the Academy, M. Verneuil says: ‘It is incorrect to say that laboratory experiments give certainty to medicine, and make it scientific instead of empirical. The fact is that experimentation has put forth as many errors as truths. ”

“ Experiments may be made, in course of researches, of very great interest and importance to medical science; and, on the contrary, they may be performed merely to demonstrate phenomena about which there is no doubt, or to impress on the memory of a student some well-known fact. They may be performed by men like Sir Charles Bell, who hesitated to confirm one of the greatest physiological discoveries of the last century, merely because it would imply a repetition of painful experiments ”

“ The Effect on Teachers or Practitioners of Medicine.—In considering the subject of experimentation, reason requires that we realize the necessary distinction between the methods employed in training students for a practical profession and the exceptional position of the few geniuses who possess the rare combination of qualities essential to scientific investigation. ”

“ The proper and only object of all justifiable experiments on animals is to determine unknown facts in physiology, pathology, and therapeutics, whereby medical science may be directly or indirectly advanced. When, therefore, any fact of this kind has been once determined and positively acquired to science, all repetition of experiments for its further demonstration are unnecessary, and therefore unjustifiable. ”

“ In 1875 some of the most distinguished surgeons and physicians of Great Britain testified before the Royal Commission that as medical students they had never witnessed an experiment on a living animal. ”

“ All experiments made with an intelligent purpose by a scientific man or medical practitioner upon himself.
3. All experiments made with their consent upon physicians, surgeons, pathologists, medical students or other scientific men, who, aware of the nature of the investigation and of possible results, voluntarily offer themselves as "material." ”

“ That no scientific, medical or surgical experiment of any kind, liable to cause pain or distress or injury to health or danger to life, shall be permissible under any circumstances upon any new-born babe, or upon any infirm or aged or feeble-minded person, or upon anyone whose mental faculties are impaired, either temporarily or permanently, or upon any woman during pregnancy or within a year after her confinement, or upon any child under fifteen years of age, unless it be undertaken for the sole benefit of the person to be experimented upon ”

“ To doubt is not to dishonour; it is the highest tribute we may pay to Science; for "without doubt, there is no inquiry, and without inquiry, no knowledge."
CHAPTER XVI RESEARCH WITHOUT VIVISECTION No phase of modern science so closely touches the welfare of humanity as the studies which concern the prevention of disease. Up to a very recent period, well within the lifetime of many now living, practically the entire energy of the medical profession was given up to the treatment of human ailments, with an almost complete disregard of problems of prevention or studies of origin. ”

“ It can hardly be but that the modes of investigating disease ordinarily followed, labour under some radical errors or defects, else the researches of ages, pursued, as they have been, with exemplary diligence, and, in many splendid instances, by minds of the first order of intellect, must, ere this, have rendered our knowledge of the nature and treatment of disease more certain and more complete. ”

“ At a period when pathological research is lending its aid in investigating the appearances of disease in every part of the body, and many nice distinctions in diagnosis are aimed at, which are better calculated for nosological than practical purposes, it seems to me not a little extraordinary, that so few have cultivated that most important branch of medicine, the study of the diseases of children. ”

“ The more nearly the treatment of diseases can be brought throughout to this degree of accuracy, the more scientific will the art of physic become, and the tendency of all medical observation and of all medical writing, should be to advance in this direction. ”

“ Whatever skill we may boast in investigating the nature of a disease, or in understanding the structure of the body, yet without a knowledge of the instruments which are to be used, and of their properties and action upon the body, whereby they produce a change from sickness to health, other knowledge avails little in the cure of diseases.
The Theory of Physic, more commonly termed Medical Institutions, comprehends under it, the important doctrines of Physiology and Pathology. ”

“ The necessity of discriminating between physic and surgery will more manifestly appear when we consider, that they are distinct in their nature, and that either of them is an art, sufficient of itself to engage the industry of one man to cultivate.
The various branches of knowledge which compose the science of medicine, are Anatomy, Materia Medica, Botany, Chymistry, the Theory of medicine, and the practice. ”

“ No doubt both clinical study and pathological observation have not only helped practical medicine onward, but they have also greatly contributed to the progress of physiology itself. In fact, I find it impossible to separate exact clinical and pathological work from scientific research of a purely physiological nature. Is not all treatment more or less experiment? ”

“ The genesis of discovery in biology, with its necessary relations to therapeutics, has yet to be written. Extending experience is more and more clearly showing us, as a practical fact, that whilst observation and rational—i.e., humanely limited—experiment are legitimate and noble efforts for the [Pg 122] attainment of improved medicine, cruel and merely curious experiment, condemned by our moral faculties, are misleading and mischievous. ”

“ It is not one of those certain or exact sciences in which truths become established and fixed, but is essentially progressive in its nature, enlarging with the growth of human experience, and subject to those changes and revolutions incident to any branch of human inquiry, the laws of which are not fully ascertained. The labors of the anatomist, the physiologist, and the chemist have contributed an immense storehouse of facts; but the manner in which this knowledge is to be applied in the treatment and cure of diseases has been, and will probably continue to be, open to diversity of opinion. ”

“ These accessory sciences have considerably developed in the evolution of medicine, and the art of medicine has become the chief motive power which urges men to research and discovery in the biological sciences, such as histology, embryology, comparative anatomy and physiology, anatomy and physiology of the brain, bacteriology, etc. Pure science now occupies such a position in medical studies that the "healing art" often remains in the background ”

“ Such demonstration is a thrilling spectacle to inexperienced students. It appeals to that love of excitement which makes them rush to a surgical operation, or to an extraordinary medical case which may have no bearing whatever on their future practice, whilst the commonplace but all-important bedside observation seems dull in comparison. Yet patient work in the anatomical and microscopic rooms, and in the chemical laboratory for general and animal chemistry, and close clinical study, all of which involve no form of suffering, are of primary importance. ”

“ Physiology prepared the way for Pathology, and the Principles and Practice of Medicine placed the experience of the whole world under contribution. Therapeutics claimed for her use the vegetable, mineral and animal kingdoms, the collateral sciences became cultivated as auxiliaries, and Botany, Mineralogy, Chemistry and Zoölogy became branches of medical study ”

“ The use of our instruments of precision, our knowledge, of pathology, all tend to narrow that bridge which must extend as a connecting link between empirical treatment, and treatment depending for its success upon a comprehensive knowledge of the natural history of disease. ”

“ The immediate object of physiological experiment is, then, not to make out new practical methods of treating disease, but rather to attain to a more complete and sound understanding of those general laws which govern the actions of the living body in health—laws which must ever form the only firm basis of the knowledge of disease, and the only sure guide to judicious modes of treatment. ”

“ It is by the recognition of this true method of biological research and by the generous support of physiologists who honestly seek for truth, even when opposed by temporary fashions of medical opinion, that medicine will become a science. ”

“ If in this brief article, which does not purport to be more than a sketch of the tremendous strides made by medicine in the Nineteenth Century, so much space has been given to the germ theory of disease, it is because the demonstration of the truth of that theory has been absolute, and has constituted the very marrow of almost all the medical progress of the century that has been the outcome of continuous thought and study as opposed to chance discovery. ”

“ There can be no question, then, as to the nature or the value of the connection between medicine and the biological sciences. There can be no doubt that the future of pathology and of therapeutics, and therefore that of practical medicine, depends upon the extent to which those who occupy themselves with these subjects are trained in the methods and impregnated with the fundamental truths of biology. ”

“ Medical research is under-endowed and stupidly endowed, not for systematic scientific inquiry so much as for the unscientific seeking of remedies for specific evils—for cancer, consumption, and the like. Yet masked, misrepresented limited and hampered, the work of establishing a sound science of vital processes in health and disease is probably going on now, similar to the clarification of physics and chemistry that went on in the later part of the eighteenth and the early years of the nineteenth centuries. ”

“ It is our pride that medicine, from an art, and a pretty black one at that, originally, is becoming a science. And the most powerful factor in this development, its indispensable basis, in fact, has been the invention of instruments of precision—the microscope, the fever thermometer, the stethoscope, the ophthalmoscope, the test-tube, the culture medium, the triumphs of the bacteriologist and of the chemist. Any man who makes a final diagnosis in a serious case without resorting to some or all of these means is regarded—and justly—as careless and derelict in his duty to his patient. ”

“ The Materia Medica and Botany may very properly be termed the natural history of medicine, as from these branches of science we derive our knowledge of that part of natural history, which more immediately relates to the health giving arts. How worthy of a Physician, a Philosopher or a Gentleman, is the knowledge of the different productions of nature taken in its full extent? I cannot too earnestly recommend this study to young men, to qualify them for every useful profession that is conversant about natural objects, and especially for the study of medicine. ”