Robert Hooke,
Micrographia
(1665)
“ I found the Down begin to make my hand itch, and in some places to smart again, much like the stinging of a Flea or Gnat, and this continued a pretty while, so that by degrees I found my skin to be swell'd with little red pustules, and to look as if it had been itchie. But suffering it without rubbing or scratching, the itching tickling pain quickly grew languid, and within an hour I felt nothing at all, and the little protuberancies were vanish'd. ”
